Study of Alteration of Lipid Profile in Chronic Kidney Disease

Jayesh, Narayanan (2012) Study of Alteration of Lipid Profile in Chronic Kidney Disease. Masters thesis, Coimbatore Medical College, Coimbatore.


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INTRODUCTION: Lipid disorders are one of the major metabolic abnormalities associated with CRF. The common components of dyslipidemia in CRF are increased triglycerides, decreased HDL cholesterol and moderate rise in total cholesterol. Ischemic heart disease is one of the major contributor for mortality in CRF patients. As the dyslipidemias can accelerate the atherosclerosis, understanding and treating this dyslipidemias is essential. METHODS: Here 40 patients with non diabetic kidney disease are studied and their lipid profiles are compared with 30 matched healthy controls. Comparisons are also made between dialysed and non dialysed patients and based on their creatinine levels. RESULTS: Plasma triglycerides &VLDL fractions are significantly elevated in CRF patients(173±54.8& 34.8±3.1) when compared with controls (96.6±15.9& 19.2±3.1). HDL was (48.6±9.6& 36.1±4.5) decreased. Cholesterol values doesn’t show any significant change. Changes in triglyceride& VLDL levels are more marked in hemodialysed patients(217.53±45& 43.6±9.1) when compared with patients managed conservatively (152.5±44.7& 30.5±8.8). There was no positive correlation between severity of dyslipidemias and serum creatinine levels. CONCLUSIONS: Uremic dyslipidemia is a metabolic abnormality associated with CRF. Its seen in both hemodialysed and conservatively managed patients. Increased triglycerides and VLDL are the common abnormalities. Reduced HDL is also seen. Triglycerides &VLDL levels are more in patients on HD when compared to patients on conservative management.There was no positive correlation between severity of dyslipidemia & serum creatinine levels among CRF patients. Dyslipidemias in CRF patients has to be treated as these can contribute to atherosclerosis and thus mortality in CRF patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Alteration, Lipid Profile, Chronic Kidney Disease.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 12 Sep 2020 16:43
Last Modified: 12 Sep 2020 16:43

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