Prevalence of Red Cell Antibodies in Antenatal Mothers

Swathandran Hamsavardhini, (2012) Prevalence of Red Cell Antibodies in Antenatal Mothers. Masters thesis, The Tamilnadu Dr. M.G.R. Medical University, Chennai.


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BACKGROUND & OBJECTIVES: Hemolytic disease of the newborn can be caused by incompatibility of maternal and fetal erythrocyte for Rh (D) or other blood type antigens. Routine antibody screening is advocated in all antenatal mothers, irrespective of whether they are Rh positive or Rh negative, to look for clinically significant antibodies other than Rh (D) that might cause haemolytic disease of the newborn. The purpose of this study was to assess the Prevalence of Red Blood Cell Antibodies in Antenatal Mothers. METHODS: A prospective analysis of red cell antibody screening test in antenatal mothers was undertaken over a period of one year. RESULTS: There were 1225 antenatal mothers included in the study. The prevalence of irregular antibodies in antenatal mothers was 1.1 %. In the overall prevalence the percentages of anti-D and non-anti-D antibodies were 76% in Rh D Negative mothers and 24% in Rh D positive mothers respectively. CONCLUSION: Prevalence of Red blood cell alloantibody in antenatal mother was 1.1% with Anti-D still being the most common antibody in Rh D negative mothers similar to the findings in others studies conducted in India. This study has also detected 3 cases of non-anti-D antibodies, one each of Antic, Anti-Lea and an inconclusive antibody in Rh D Positive mothers. This study also included one inconclusive antibody, which needs to be further elucidated with indigenously developed cell panel for our population.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Red cell Alloantibody, hemolytic disease of the new born.
Subjects: MEDICAL > Immunohaematology Blood Transfusion
Depositing User: Subramani R
Date Deposited: 11 Sep 2020 17:15
Last Modified: 11 Sep 2020 17:15

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