Sumathi, S (2011) Study of Lipid Peroxidation in Diabetes Mellitus. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
INTRODUCTION : Diabetes mellitus is a group of metabolic disease characterized by Hyperglycaemia resulting from defects in Insulin secretion, Insulin action Or both. It is a complex disease where carbohydrate, protein and fat Metabolism is impaired. Diabetes is an “ice berg” disease. The number of cases of diabetes World wide is estimated to be around 150 million. It is estimated that 20 Percent of the current global diabetic population resides in South- East Asia Region. In India, the prevalence of disease in adults was found to be 2-4 Percent in rural and 4 – 11.6 percent in urban dwellers. High frequencies Of impaired glucose tolerance, shown by studies ranging from 3.6-9.1 Percent indicate the potential for further rise in prevalence of DM in the coming decades. AIM OF THE STUDY : 1. To study the level of lipid peroxide in IDDM and NIDDM. 2. To find out the correlation between Lipid peroxide and Lipid Profile in both types of diabetes mellitus. 3. To find out the correlation between lipid peroxide with glycaemic Control (HbA1C). MATERIAL AND METHODS : Participants of the study group were selected from the outpatients population of Department of Diabetology, Thanjavur Medical College, Thanjavur. 100 patients were selected for this study. Out of which 50 patients belong to NIDDM and 50 to IDDM group. 50 persons served as healthy control. Inclusion Criteria: All ambulatory NIDDM and IDDM patients without any complications. Exclusion Criteria : Smokers, Alcoholics, Renal failure, Bronchial Asthma. For all the patients, fasting and post prandial blood samples and fasting urine samples were collected. For blood sugar estimation, blood collected in fluorinated tube. CONCLUSION : It is evidenced that the level of MDA is increased in both types of DM. There is significant increase in levels of plasma Total cholesterol, TGL,LDL and VLDL and significant decrease in levels of HDL in both types of DM. To conclude in the era of modern medicine diabetic complications demand prevention and management. The estimation of lipid peroxide along with lipid profile in diabetes mellitus is very useful as it may serve as a useful monitor to judge the prognosis of the patient. The detection of risk factor in the early stage of the disease will help the patient to improve and reduce the morbidity rate. It is with this background that the ray of hope provided by the considerable evidence suggesting the role of prevention of increased lipid peroxidation could offer feasible and cost effective way to reduce the prevalence of diabetic complications.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Lipid Peroxidation ; Diabetes Mellitus. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 11 Aug 2017 01:23 |
| Last Modified: | 11 Aug 2017 01:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1302 |
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