Lourdu Jafrin, A (2010) A Study on the Anxiolytic and Sedative Effects of Ondansetron in Mice. Masters thesis, Madurai Medical College, Madurai.
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Abstract
Past attempts to treat anxiety disorders have only been partially successful. Several converging lines of evidence from molecular, animal and clinical studies have demonstrated that the GABAA – Benzodiazepine receptor complex plays a central role in modulation of anxiety. Benzodiazepines, which act at this receptor, have anxiolytic properties, but are limited by side effects like sedation, tolerance and concerns of potential abuse/dependence. Ondansetron, a selective 5HT3 antagonist, used as antiemetic in post operative nausea and vomiting (PONV) and cancer chemotherapy induced emesis, produces significant anxiolysis at the antiemetic dose itself. Hence ondansetron could reduce the stress which frequently accompanies the above conditions and also reduce the need for additional anxiolysis. From the present study a significant anxiolytic effect without the sedative side effect of benzodiazepines was found to be present for ondansetron in mice. Therefore ondansetron could become an alternative anxiolytic with better patient compliance. Further studies are warranted to explore the long term effects in treating anxiety disorders in humans as well as for the development of tolerance. Also whether other 5HT3 antagonists also exhibit anxiolytic effects is still to be determined.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anxiolytic and Sedative Effects, Ondansetron, Mice. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Aug 2020 14:29 |
| Last Modified: | 23 Aug 2020 14:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12977 |
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