Clinicopathological analysis of ovarian tumours and the role of ER, PR, HER-2/NEU in surface epithelial tumours of ovary

Priya, T (2016) Clinicopathological analysis of ovarian tumours and the role of ER, PR, HER-2/NEU in surface epithelial tumours of ovary. Masters thesis, Thanjavur Medical College, Thanjavur.

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Abstract

Ovarian cancer is 6th most common cancer in women worldwide. It has been suggested that incessant ovulation and gonadotrophin stimulation may play a role in development of ovarian cancer. Ovarian cancer carries highest mortality among all gynaecological cancers because the early stages are asymptomatic. The tumour is diagnosed only in late stages (Stage III and IV). No effective screening methods are available as in cervical cancer. Epidemiological evidence suggests that steroid hormones (estrogen and progesterone) and amplification of Human epidermal growth factior-2 (HER-2/neu) gene are implicated in ovarian carcinogenesis. Thus the steroid hormone receptor positivity on the ovarian surface epithelium and ovarian carcinoma is of paramount significance for hormonal therapy. This study is undertaken to review the incidence of ovarian neoplasm in our institution. A total of 132 cases were evaluated in concordance with clinical history, histopathological features. Immunohistochemistry (ER, PR) was done for surface epithelial carcinomas. HER-2/neu expression was compared between malignant surface epithelial carcinomas and borderline tumours. Ovarian malignancy (4.1%) was found to be the second most common malignancy in female genital tract next to cervical malignancy. In our institution surface epithelial tumour (68.9%) was the most common neoplasm. Mucinous cystadenoma was the commonest tumour. Positive ER(36.3%) and PR(45.4%) expression in surface epithelial malignancies proves the mitogenic role of estrogen and progesterone. HER-2/neu showed positive expression in surface epithelial malignancies only (60% serous and 33.3% of mucinous carcinomas). Negative expression was seen in borderline tumours. Hence HER-2/neu helps in differentiating borderline and malignant tumours. Thus a panel of markers will be helpful in prognostication of ovarian tumours and development of targeted therapy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Ovarian cancer ; Surface Epithelial Tumours ; Estrogen receptor ; Progesterone receptor ; Human Epidermal Growth Factor.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 10 Jul 2017 07:58
Last Modified: 26 Nov 2018 17:24
URI: http://repository-tnmgrmu.ac.in/id/eprint/1290

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