An immuno-epidemiological study on the effect of Neonatal BCG vaccination on intracellular killing of Mycobacterium tuberculosis by human macrophages.

Mathan Periasamy, C (2009) An immuno-epidemiological study on the effect of Neonatal BCG vaccination on intracellular killing of Mycobacterium tuberculosis by human macrophages. Doctoral thesis, The Tamilnadu Dr. M.G.R. Medical University, Chennai.

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Abstract

Tuberculosis (TB) was the first disease to be declared a global emergency by the World Health Organization in 1993, an honor not even enjoyed by small pox. It is an infectious disease caused by Mycobacterium tuberculosis mainly and sometimes other closely related Mycobacterium strains M. africanum and M. bovis which are commonly known as the TB-complex. The pathogen M. tuberculosis infects approximately 32% of the world human population and about 10% of the infected develop the disease. An Immuno-epidemiological study was performed to study the effect of neonatal BCG vaccination and tuberculin response on macrophage killing profile. In epidemiological field work part, the study subjects were drawn from three different study areas; urban, sub-urban and rural in and around Chennai city. The descriptive epidemiological pattern of neonatal BCG vaccination, its impact on tuberculin skin test and certain common risk factors associated with the tuberculin skin test reactivity were studied. Finally the study subjects for the immunological laboratory experiments were recruited and were grouped in to four natural study groups as; Study Group 1 Vaccinated reactors Study Group 2 Vaccinated non-reactors Study Group 3 Non-vaccinated reactors Study Group 4 Non-vaccinated non-reactors In Immunological laboratory work part, the elucidation of macrophage killing profile was studied for all the four groups. The parameters used for the macrophage killing profile were; (i) Measurement of phagocytosis, (ii) Superoxide dismutase assay, (iii) Glutathione assay, (iv) Tumour necrosis factor-

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: BCG vaccination; Neonatal; Mycobacterium tuberculosis; Human macrophages; Immuno-epidemiological study; Intracellular killing
Subjects: MEDICAL > Community medicine.
Depositing User: Devi S
Date Deposited: 20 Jun 2017 07:55
Last Modified: 20 Jun 2017 08:47
URI: http://repository-tnmgrmu.ac.in/id/eprint/129

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