Muthukani, S (2014) Differentiation of benign from malignant induced ascites by measuring gallbladder wall thickness. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND : The conventional diagnostic method for most of the causes of ascites is diagnostic tapping of the ascitic fluid (paracentesis). This method is an invasive method. It is also a time consuming method.Ultrasonography has positive predictive value of 93-95% in determination of gallbladder wall thickness if the thickness is 1 mm. It is nearly 100% sensitive when the thickness is > 1.5 mm. AIMS : In our study we aim to find out the diagnostic value of ultrasonographic measurement of gallbladder wall thickness in differentiation of cirrhotic ascites from peritoneal carcinomatosis induced ascites. We also study the relationship between serum albumin levels and gallbladder wall thickness PATIENTS AND METHODS : We have included 60 patients in our study. Patients admitted with chronic liver disease with ascites, malignant induced ascites at medical wards, Institute of Internal medicine.Patients are subjected to routine blood investigations like complete blood count,renal function tests, liver function tests, PT-INR. Patients Gallbladder wall thickness will be assessed by Ultrasonography after 8 hours of fasting with fill gallbladder. Three measurements of gallbladder wall thickness were taken at each site and average measurement was used for analysis. A single operator performed all the ultrasound examinations both in cirrhotic patients and peritoneal carcinomatosis patients. Real time bidimensional and Doppler ultrasound examinations were performed by using 3.5 MHz transducer. Thickness more than 3 mm was considered significant. CONCLUSION : According to our study, thesonographic study of the gallbladder will be helpful as a simple and initial screening tool in differentiating between cirrhosis induced and peritoneal carcinomatosis induced ascites. Hypoalbuminemia is correlated well with the development of thickened gallbladder in cirrhosis induced ascites.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Gallbladder wall thickness, Serum Albumin, Prothrombin time, International normalized ratio, Ultrasonogram. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Pushparaj A |
| Date Deposited: | 10 Jul 2017 11:33 |
| Last Modified: | 02 Feb 2018 02:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1283 |
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