Anti-Hypertensive Activity of Thennampoo Chooranam (Cocos Nucifera, Linn) & Anti-Ulcer Activity of “Gunma Noikku Mezhugu”

Sumathi, V (2012) Anti-Hypertensive Activity of Thennampoo Chooranam (Cocos Nucifera, Linn) & Anti-Ulcer Activity of “Gunma Noikku Mezhugu”. Masters thesis, Government Siddha Medical College, Chennai.

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Abstract

THENNAMPOO CHOORANAM: The drug “dried flower of Cocos nucifera chooranam has taken for study to prove its efficacy on the management of High Blood Pressure. The herb Cocos nucifera flower was collected from S.Malaiyanur, Villupuram (Dt.) Tamilnadu and purified then powered and stored. This drug was subjected to various studies. Literary collections revealed the test drug’s effectiveness in the treatment of Raktha kothippu (Hypertension). Botanical aspect of the drug of coconut flower was studied regarding its identification, description, and chemical constituents from the siddha and modern literature. Gunapadam aspect ‘Cocos nucifera flower is indicated for treating Raktha Kothippu comes under the ‘Pitha ’ disease .So the therapeutic efficacy to use in hypertensive patients at Government Siddha Medical College, Chennai. Pharmacognostic study is performed in CRI Arumbakkam, Chennai-106, for identification and botanical aspect of the test drug. Physio-chemical analysis and TLC pattern of the study was was performed in CRI Arumbakkam, Chennai-106 for physical properties and separation and identification of various compounds present in the test drug. The Bio chemical analysis of the test drug carried out in SAIF IITM, Chennai-36 and its showed the presence of Calcium, Potassium, Iron, Magnesium, Sulphate, Chloride, Phosphate. The phytochemical study is performed in Government Siddha Medical College of Botany lab,Chennai-106, and it showed the presence of Tannin, Alkaloids, Flavanoids, Volatile oil ,Cardio glycosides (trace) ,Carbohydrates. The toxicological study & pharmacological study was carried out Vels University of Pharmacological Department, Pallavaram,Chennai-117,and the study showed that the test drug has safety and no toxic effect, it has significant the Anti-hypertensive and good Diuretic, Anxiolytic effect. The therapeutic trials were conducted Gunapadam post graduate out patient and inpatient department, Government Aringar Anna Hospital for Indian Medicine and Homoeopathy, Chennai – 106,and the study showed that drug has act the blood pressure gradually comes down with in 2 weeks and to become good response in 74% cases. GUNMA NOIKKU MEZHUGU: The drug “Gunma noikku mezhugu has taken for study to prove its efficacy on the treatment of Gunmam(Peptic ulcer disease). To collect the information about the drug, various text books, Literature were referred. From them, the author came to an idea about the drug and its efficacy on Gunmam. A brief description about botanical aspect of the test drug and its identifying characters and Phyto chemical data’s were given. The Phyto chemical analysis of the drug shows that it contains Potassium, Calcium, Sodium, Magnesium, Iron, It is related in treatment of Gunmam. The pharmacological analysis showed that the drug has got significant Anti ulcer activity. In clinical study the drug has showed 70% of cases. The patients were responding well from the beginning of the treatment and no adverse effects were reported. This present study suggests that Gunma noikku mezhugu has the remarkable medicinal value against the disease GUNMAM. Improvements of signs and symptoms by statistical analysis shows the two tailed “p” value equals 0.03 by conventional criteria, this difference is considered to be very statistically significant. From the above results p < 0.05, it shows the improvement in the subjective parameters produced by Gunma noikku mezhugu statistically significant. All above studies of “Gunma noikku mezhugu” appears to be a good efficacy in the treatment of pepticulcerdisease.

Item Type: Thesis (Masters)
Additional Information: Reg.No.32091609
Uncontrolled Keywords: Anti-Hypertensive Activity, Thennampoo Chooranam, Cocos Nucifera, Linn, Anti-Ulcer Activity, Gunma Noikku Mezhugu.
Subjects: AYUSH > Gunapadam
Depositing User: Subramani R
Date Deposited: 02 Aug 2020 14:37
Last Modified: 02 Aug 2020 14:37
URI: http://repository-tnmgrmu.ac.in/id/eprint/12718

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