Sharmila, B (2008) Efficacy of Topical 1% Fluconazole Gel in Dermatophytosis. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION: The accelerating pace of change in medicine stems from an explosion of scientific information and there is a need to blend this information into the art and practice of medicine. The challenge of managing skin diseases lies not only in proper diagnosis, but also in the use of correct drug without causing any discomfort to the patient. It is also of cosmetic importance and infact this is the cause for anxiety, both among the young and the older people. Superficial fungal infections are caused by Dermatophytes and are termed Dermatophytosis. The Dermatophytes are a group of taxonomically related fungi, which have the ability to form attachment to keratin, that is Stratum corneum of the epidermis, hair, nails and the horny tissues of animals. Fungal infection of the skin is very common in India. In the Department of Dermatology, Stanley Medical College and hospital where the study was conducted, incidence of fungal infection for the year 2006 was 12%. The Dermatophyte infection was 8% and the remaining fungal infections were 4%. AIM OF THE STUDY: To determine the efficacy of topical 1% Fluconazole gel in Dermatophyte infections. OBJECTIVES: 1. To evaluate Topical 1% Fluconazole gel in Dermatophyte infections. 2. To compare the efficacy of Topical 1% Fluconazole gel with orally administered Fluconazole tablet and Topical 1% oxiconazole cream. METHODOLOGY: Informed written consent is obtained from the patient in their own language, after explaining in detail about the study. The patients who are included in the study are randomised in 3 groups. 60 patients are alloted to each group. Before starting the therapy, basic investigations for blood urea, sugar, serum creatinine and haemogram were done, in appropriate cases. RESULTS: The results of the study is analysed and Oneway ANOVA and Chi Square tests were used to compare the results. 60 patients were enrolled in each group. The mean age of patients in group1, who were treated by application of topical Fluconazole gel is 33.73 and the mean age of patients in group 2, who received oral Fluconazole tablet, on weekly basis, has been found to be 35.28. The mean age of patients in group 3, who were treated by applying oxiconazole cream is 34.83. The age distribution is shown in table number2. There is no significant difference in the age of the patients enrolled in all the three groups. The number of patients in the various age groups enrolled in the 3 trial groups has also been analysed and is presented in table number 3.This also shows no significant difference among the 3 groups. CONCLUSION: This study was taken up in the Department of Dermatology, Stanley Medical College, Royapuram, Chennai. The study was taken up to assess the efficacy of Topical Fluconazole gel in Dermatophytosis. The efficacy of topical Fluconazole gel was compared with topical Oxiconazole cream and once a week orally administered Fluconazole tablet. Fluconazole was available only for oral therapy and topical Fluconazole is a recent introduction. Hence, this study was taken up to determine its antifungal efficacy, in unique situations prevailing in this part of the country. Topical Fluconazole has been proved to be very effective in Tinea infections. Though, oral Fluconazole tablet, given once a week was expected to produce equally effective response, the results actually showed the reduced effectiveness, when compared with topical formulation. This is a serendipitious observation. More studies at different centres are required to confirm this finding. Studies to find out the efficacy of oral Fluconazole tablet administered in a smaller dose, on daily basis is also essential to find out the effectiveness of such therapy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Efficacy, Topical 1% Fluconazole Gel, Dermatophytosis. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 31 Jul 2020 17:58 |
| Last Modified: | 01 Aug 2020 06:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12685 |
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