Kannan, S (2009) A Study on Anxiolytic, Sedative and Hypnotic Activities of Aqueous Extract of Morinda Citrifolia Fruit in Mice. Masters thesis, Madurai Medical College, Madurai.
|
Text
200600309kannan.pdf Download (2MB) | Preview |
Abstract
Anxiety disorders constitute highly disabling and prevalent conditions. However, past attempts to treat these disorders have only been partially successful. Several converging lines of evidence from molecular, animal and clinical studies have demonstrated that the GABAA – Benzodiazepine receptor complex plays a central role in modulation of anxiety. Benzodiazepine, which act at this receptor, have anxiolytic properties, but are limited by side effects like tolerance and concerns of potential abuse/dependence. Noni, Morinda citrifolia, is a highly regarded folk remedy which appears to be beneficial to health in numerous ways. Since Parkinson’s description of noni fruit as a food in 1769, many studies were done and its safety was proved over a wider range of doses and it is practically nontoxic. From the present study a significant anxiolytic, seadative and hypnotic effects were proved to be present with aqueous extract of Morinda citrifolia fruit. Further studies are warranted to explore the long term effects in treating anxiety disorders as well as for the development of tolerance and potential for drug abuse.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anxiolytic, Sedative and Hypnotic Activities, Aqueous Extract, Morinda Citrifolia Fruit, Mice. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 31 Jul 2020 17:55 |
| Last Modified: | 01 Aug 2020 04:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12682 |
Actions (login required)
 |
View Item |
