Gomathi Priya, J (2017) Vitamin D status in Children with Autoimmune Thyroiditis. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Deficiency of 25 hydroxyvitamin D has been linked with predisposition to autoimmune disorders. Also vitamin D has been found to be a causal factor in many autoimmune diseases. This relationship is being investigated to study the role of this hormone in autoimmune thyroid diseases. OBJECTIVE: To investigate vitamin D status in children with autoimmune thyroiditis. METHODS: It is a case control study done in Department of Endocrinology, Institute of Child Health, Egmore, Chennai during the period of August 2015 to September 2016. 75 children (70 female, 5 male) with age and sex matched healthy controls were chosen. Free thyroxine, TSH, anti TPOAb, anti TGAb, 25 hydroxyvitamin D, serum calcium, phosphorus, alkaline phosphatase levels were estimated in both cases and control subjects. Children with anti TPO or anti TG positivity were divided into four groups based on their level of antibody titers. RESULTS: The mean age in cases was 9.8 ± 0.34 years. It was found that there was no significant difference among the groups in both anti TPO (p< 0.283) and anti TG (p<0.148). 25(OH)D levels were significantly lower in cases (15.07 ± 1.14 ng/ml) compared to controls (17.82 ± 1.13 ng/ml) (p<0.0006). Mean serum calcium levels in cases (9.35 ± 0.16 mg/dl) were lower when compared to controls (9.73 ± 0.14 mg/dl). This difference is statistically significant (p<0.0005). Similarly mean alkaline phosphatase level in cases (184.97 ± 11.10 IU/L) was significantly elevated when compared with controls (122.37 ± 6.82 IU/L) (p<0.0001). However there was no significant difference in serum phosphorus levels between cases (4.42 ± 0.10 mg/dl) and controls (4.43 ± 0.14 mg/dl) (p=0.83). In Hashimoto group, 10 (13.3%) children were euthyroid, 13 (17.3%) had subclinical hypothyroidism and 52 (69.3%) had overt hypothyroidism. But there was no significant difference in vitamin D levels between the euthyroid, overtly hypothyroid or subclinical hypothyroid groups. CONCLUSION: The significant decrease in vitamin D levels in cases signifies that 25(OH)D may be an independent causal factor related to the autoimmunity in thyroid diseases.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201417009 |
| Uncontrolled Keywords: | Autoimmune thyroiditis, vitamin D, Hashimoto. |
| Subjects: | MEDICAL > Paediatrics |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Jul 2020 17:07 |
| Last Modified: | 23 Jul 2020 17:07 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12668 |
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