Poornachand, V (2017) Study of Clinical and Biochemical Profile of Subclinical Hypothyroidism in Children. Masters thesis, Madras Medical College, Chennai.
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Abstract
OBJECTIVE: Subclinical hypothyroidism is quite a common clinical condition. Aim of the study is to understand the clinical and biochemical profile of Subclinical hypothyroidism in children attending endocrinology OPD at Institute of Child Health and Hospital for children. METHODS: We studied 62 children diagnosed with Subclinical Hypothyroidism. Clinical assessment and laboratorial evaluation was carried out in a systematic way. Symptomatology; Anthropometry; Measuring vital parameters such as Heart rate, Blood pressure; tests for Anti-thyroid antibody, lipid parameters; estimation of bone age; USG neck; assessment of left ventricular function using M-mode echo were carried out at the time of diagnosis. RESULTS: Subclinical Hypothyroidism is more common in female children, principle symptoms were neck swelling and weight gain, goitrous autoimmune thyroiditis is more common in female, significant number of children had positive anti-thyroid antibodies, mean TSH value of patients with positive anti-thyroid antibody was high, there was no delay in bone maturation in significant number of children, both Systolic and Diastolic blood pressure was high, these children have abnormal lipid profile, heart rate and Left ventricular function was normal. CONCLUSION: Subclinical Hypothyroid children have higher risk of hypertension, progression to overt hypothyroidism and pro atherogenic lipid abnormalities and needs regular follow up.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201417011 |
| Uncontrolled Keywords: | Subclinical Hypothyroidism, Autoimmune thyroid disease, Lipid abnormalities, Cardiovascular morbidity. |
| Subjects: | MEDICAL > Paediatrics |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Jul 2020 17:01 |
| Last Modified: | 23 Jul 2020 17:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12667 |
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