Kala, K (2017) Comparative Evaluation of Ropivacaine and Lignocaine with Ropivacaine, Lignocaine and Clonidine Combination during Peribulbar Anaesthesia for Cataract Surgery. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Peribulbar is the most commonly used technique of anaesthesia in cataract surgery and Ropivacaine is a new amino amide local anaesthetic with safer pharmacological profile. OBJECTIVES: A double blind , prospective, randomized study carried out in our institution after getting approval from ethical committee, to compare the anaesthetic effects of Ropivacaine with combination of Ropivacaine and clonidine in administration of Peribulbar block in cataract surgery. METHODS: A total of 80 patients of both sexes aged 40-80 years of ASA PS Ι, ΙΙ, scheduled for cataract surgery were included in this study. Patients was allocated into two groups 0f 40 each; Ropivacaine, Lignocaine group(R group) who received Peribulbar block with 2.5ml of Lignocaine (2%)+ 2.5ml of Ropivacaine (0.75%) +50 Units of Hyaluronidase to a total volume of 5 ml and Ropivacaine,Lignocaine,Clonidine group(RC group) received Peribulbar block with 2ml Lignocaine (2%)+ 2ml of Ropivacaine (0.75%) + 50 Units of Hyaluronidase +1µg/kg of Clonidine to a total volume of 5ml. Heart rate (HR), mean arterial pressure (MAP), pulse oximetry (SpO2), intraocular pressure (IOP), quality of Peribulbar block were observed throughout the intraoperative period at regular intervals. Duration of analgesia was observed in postoperative period. At the end of the study the data was subjected to statistical analysis using the Student’s "t" test and Pearson’s chi square (X 2) test. RESULTS: Demographic characteristics, Spo2 were comparable in both group. The onset of sensory and motor blockade was significantly earlier in RC group. Intraocular pressure does not vary significantly in both groups. The hear rate, mean arterial pressure was on lower side in RC group. The duration of analgesia was prolonged in RC group (6.16 hours) as compared to R group (3.48 hours). CONCLUSION: On adding Clonidine to local anaesthetic agent augments early onset and prolonged offset of sensory analgesia. It also reduces the volume of local anaesthetic requirement. They maintain the hemodynamic throughout the procedure.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201420006 |
| Uncontrolled Keywords: | Ropivacaine, Lignocaine with Ropivacaine, Lignocaine and Clonidine, Peribulbar Anaesthesia,Cataract Surgery. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Jul 2020 03:27 |
| Last Modified: | 24 Jul 2020 03:29 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12615 |
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