Gayathiri, S (2017) A Prospective, Randomized Double Blinded Comparative study of the effect of Sevoflurane on Intubating Conditions with Rocuronium in patients Undergoing Elective Craniotomies. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND AND AIMS: Rocuronium may not always be the preferred relaxant for rapid sequence intubation. When 2% sevoflurane is used in conjunction with rocuronium, it may reduce the time required for achieving complete skeletal muscle relaxation with the intubating dose of rocuronium. METHODS: This study was prospective, randomised, doubleblind in nature and compared the effect of sevoflurane on intubation time and intubating conditions when used along with rocuronium. Thirty adult patients belonging to American Society of Anesthesiologists physical status Grades 1 and 2, of either gender aged between 30 and 65 years undergoing neurosurgical operations were randomly allocated into two equal groups: Group R received 0.8 mg/kg rocuronium, and Group RS received 0.8 mg/kg of rocuronium with 2% sevoflurane. Onset time of intubation was assessed using train-of-four stimuli. The intubating conditions were compared using the Cooper scoring system and the haemodynamic responses were compared between the two groups. RESULTS: The onset time of intubation was 101.73 ± 10.28 s in Group R and 60.4 ± 4.1 s in Group RS (P < 0.001), with excellent intubating conditions in both groups and without any adverse effects. Significant differences in heart rate and mean arterial pressure were seen immediately after intubation, at 1 and 3 min (P < 0.05) between the two groups. CONCLUSION: In conclusion, inj. Rocuronium when used at a dose of 0.8 mg/kg along with 2% sevoflurane (1 MAC) provides excellent intubating conditions within 60–66 sec without any adverse effects in elective neurosurgeries. This can be used for rapid sequence intubation (RSI) during anaesthesia in neurosurgical patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.201420018 |
| Uncontrolled Keywords: | Intubating conditions, rocuronium, |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Jul 2020 03:17 |
| Last Modified: | 24 Jul 2020 02:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12608 |
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