Chandrasekaran, I (2011) A Study on the Efficacy of Gabapentin on Combined Spinal Epidural Anaesthesia for Lower Limb Orthopedic Surgeries: A study of 60 cases. Masters thesis, Madurai Medical College, Madurai.
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Abstract
60 patients of ASA I, II undergoing lower limb surgeries were randomly assigned into two groups Group G, and Group P. Surgery was done under combined spinal epidural anaesthesia. The patients in group G received three Gabapentin capsules (1200mg). In group P, three placebo capsules given. Subarachnoid block was performed with 0.5% Bupivaccine 3ml (Hyper baric). Epidural analgesia was given by 0.125% bupivacaine + Fentanyl 2μg/ml (8 ml volume). The parameters observed were time to reach T10 segment sensory blockade, two segments regression time, time to receive first epidural analgesic requirement, total number of epidural analgesic requirements, time intervals between each epidural supplementations, Ramsay sedation score and side effects. This study shows that, 1. Gabapentin does not have effect on onset of sensory Blockade of subarachnoid Block. 2. Gabapentin prolongs two segment regression time by 5minutes compared to placebo group. 3. Gabapentin prolongs duration of sensory blockade of spinal analgesia by 33 minutes compared to placebo. 4. Gabapentin significantly prolongs the time intervals between the epidural analgesic requirement by 4 hours compared to placebo (8hrs vs 4hrs). 5. Thus Gabapentin reduces the total requirements of epidural supplementation compared to placebo. 6. Patients in Gabapentin group have higher Ramsay sedation score (2-3) compared to placebo group (1-2). 7. The commonly reported side effects in Gabapentin group are dizziness, and headache. In the placebo group head ache is the commonly reported side effects and no patients in placebo group reported dizziness. This provides an evidence of the Gabapentin action on Acute pain relief by acting on NMDA receptor and voltage gated calcium channel by acting on central nervous system. CONCLUSION: Gabapentin before surgery significantly prolongs two segment regression time and duration of analgesia in subarachnoid blockade and it significantly reduces the post operative epidural analgesia requirements.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Gabapentin, Spinal Epidural Anaesthesia, Lower Limb Orthopedic Surgeries. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Jul 2020 02:32 |
| Last Modified: | 21 Jul 2020 02:32 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12600 |
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