Dipin Mani, (2017) A Study on the Effectiveness of Dexmedetomidine and Esmolol for Induced Hypotension in Functional Endoscopic Sinus Surgeries. Masters thesis, Kanyakumari Government Medical College Hospital, Nagercoil.
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Abstract
BACKGROUND: Induced Hypotension is a method used to reduce bleeding and thereby improve the quality of surgical field during FESS. This study compares the efficacy and safety of Dexmedetomidine and Esmolol s hypotensive agents in Functional Endoscopic Sinus Surgeries. AIM OF THE STUDY: To compare the efficacy of Dexmedetomidine and Esmolol for induced hypotension in Functional Endoscopic Sinus Surgeries. METHODS: We included 60 ASA l &ll patients in the study. Patients were randomly allocated to two groups. Group A (n= 30) : Patients receiving Dexmedetomidine. Group B (n= 30) : Patients receiving Esmolol. In Group A, patients received loading dose of 1 μg/kg Dexmedetomidine diluted in 10 ml 0.9% saline infused over 10 min, before induction of anesthesia, followed by continuous infusion of 0.4 – 0.8 μg/kg/h. In Group B, patients received Esmolol as a loading dose 1 mg/kg, infused over 1 min, before induction of anesthesia, followed by continuous infusion of 0.4-0.8 mg/kg/h. The surgical field was assessed using Average Category Scale. Intraoperative hemodynamic parameters, Emergence time, and postoperative sedation scores were recorded. RESULTS: Both Dexmedetomidine and Esmolol were effective in maintaining the intraoperative mean arterial pressure within the target range. Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were comparable between the two groups during the intraoperative period till the stoppage of the study drug. Average Category Scale was comparable between the two groups. Emergence time and the time to achieve Aldrete score ≥9 were significantly lower in Esmolol group compared with Dexmedetomidine group. The sedation scores were significantly lower in Esmolol group compared with Dexmedetomidine group at 20 and 40 minutes postoperatively. CONCLUSION: Both Dexmedetomidine and Esmolol are effective in providing ideal surgical conditions during Functional Endoscopic Sinus Surgery. Dexmedetomidine has the advantage of longer post operative pain relief. However, Esmolol has the advantage of faster recovery compared to Dexmedetomidine.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.201420601 |
| Uncontrolled Keywords: | Induced Hypotension, Functional Endoscopic Sinus Surgeries (FESS), Dexmedetomidine, Esmolol. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Jul 2020 01:04 |
| Last Modified: | 21 Jul 2020 01:04 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12591 |
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