Amarnath, S (2017) The Value of Perfusion CT Imaging in Space Occupying Lesions of Liver with Histopathological Correlation. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: A discrete abnormality arising within the liver is defined as a space occupying lesion in the liver. Space occupying lesions of the liver can be divided into developmental, neoplastic, inflammatory and miscellaneous. Currently, there is no consensus concerning the optimal strategy for imaging the liver for space occupying lesions. Various imaging modalities for liver are often used based on the availability of equipment and experience of the radiologists and the requests of referring physicians. AIMS AND OBJECTIVES: To compare the imaging diagnosis of liver lesions (especially the atypical lesions ) using CT perfusion parameters with the histopathological diagnosis and to analyse the correlation between CT perfusion parameter values of normal liver parenchyma with various benign and malignant lesions of the liver and also to analyse the correlation between CT perfusion parameter values of normal liver parenchyma with some of the common benign and malignant lesions of the liver in these study group. MATERIALS AND METHODS: The study population consisted of 50 patients diagnosed as benign / malignant liver lesion on US / CT / MRI and referred for CT perfusion imaging at Barnard Institute of Radiology, Madras Medical College. Time-attenuation curves were obtained and quantitative perfusion parameters were calculated by applying body perfusion software. Six types of parameter maps [Blood Flow (BF), Blood Volume (BV), Permeability (PERM), Arterial Liver Perfusion (ALP), Portal Venous Perfusion (PVP) & Hepatic Perfusion Index (HPI)] were generated for each patient and were compared with histopathology. RESULTS: Among 50 patients in the study group , 26 patients had malignant and 24 patients had benign lesion on histopathology. Comparing the CT perfusion parameters between malignant and benign liver lesion using the Unpaired sample t-test showed that there is a highly significant increase of BF, BV, PERM, ALP & HPI among malignant group versus benign group (p <0.01). CONCLUSION: CT perfusion is a non-invasive, quantifiable, and feasible technique allowing quantitative assessment of hemodynamic changes in normal and diseased liver which is difficult to detect accurately with conventional CT and it provides functional information about the microcirculation of normal liver parenchyma and can be used to differentiate focal lesions of the liver with the perfusion parameters.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201418003 |
| Uncontrolled Keywords: | Perfusion CT Imaging, Space Occupying Lesions, Liver, Histopathological Correlation. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Subramani R |
| Date Deposited: | 20 Jul 2020 17:15 |
| Last Modified: | 20 Jul 2020 17:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12590 |
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