Bharathipriya, R (2017) Role of 3 Tesla Magnetic Resonance Spectroscopy in Intramedullary Spinal Lesions and Its Histopathological Correlation. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: A spectrum of diagnostic considerations may affect the spinal cord which includes developmental anomalies, inflammatory and infectious processes, vascular disease, degenerative conditions as well as benign and malignant neoplasms. Patients with intramedullary spinal cord lesions commonly present with tingling pain, numbness and weakness. Magnetic resonance imaging is the current imaging modality of choice in the evaluation of patients presenting with myelopathic symptoms in the search for spinal cord lesions. It is important to recognize and differentiate non neoplastic from the neoplastic process of the spinal cord as the two entities differentiation is extremely crucial to the neurosurgeon. Magnetic resonance spectroscopy is a noninvasive tool which helps to characterise the chemical composition of human tissue. Thereby it can help to better characterize pathologic processes affecting the spinal cord and also helps to provide important clinical markers for differential diagnosis. OBJECTIVE: To evaluate the intramedullary spinal cord lesions using 3T MRS and to correlate the results with HPE. METHODS: Approval for this study was obtained from our institute ethical committee.standard MRI spine and MR Spectroscopy were done on a SIEMENS SKYRA 3TESLA MRI SCANNER.MRS was performed for all patients with intra medullary spinal lesions after getting written consent .MRS was performed using single voxel and change in the metabolite peak was observed in each case and the results were compared with HPE. RESULTS: The final cohort included 50 patients, among these 29 were male and 21 were female with a mean age of around 33yrs and following changes were observed. On applying conventional MRI alone no of cases detected correctly is around 58%. On applying MRS to the conventional MRI no of cases detected is increased to 84%. On comparing the conventional MRI and MR Spectroscopy with Histopathological examination by using MCNEMAR TESTS it was found that statistically significant difference exists with a p value of 0.007. CONCLUSION: MR spectroscopy of the spinal cord is a promising tool for research and diagnosis because it can provide additional information complementary to other noninvasive imaging methods. It is an emerging tool - adds new biomarker information for characterization of spinal cord tumors, to differentiate benign and malignant lesions, to prevent unnecessary biopsies and surgeries. However, the application of MR spectroscopy in the spinal cord is not straightforward, and great care is required to attain optimal spectral quality.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201418002 |
| Uncontrolled Keywords: | 3 Tesla Magnetic Resonance Spectroscopy, Intramedullary Spinal Lesions, Histopathological Correlation. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Subramani R |
| Date Deposited: | 20 Jul 2020 17:08 |
| Last Modified: | 20 Jul 2020 17:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12589 |
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