Gowthami, R (2017) Morphological Changes in the Red Blood Cells as a Marker of Oxidative Stress in Metabolic Syndrome and Antioxidants as an Add on Therapy in the Reversal of Changes: A Randomized, Open Label, Comparative Pilot Study. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Metabolic syndrome is a cluster of hypertension, dyslipidemia, diabetes and central obesity. Psychological stress and oxidative stress plays a role in pathogenesis. Oxidative stress can also damage RBCs (Crenated cells with Heinz bodies). In this study RBC changes are taken as a marker of oxidative stress and antioxidants are given to prove free radical damage as a cause for diabetes, hypertension and dyslipidemia. OBJECTIVES: To study morphological changes of RBCs as a marker of oxidative stress and the efficacy of Vitamin C and E as add on therapy to standard treatment of metabolic syndrome. METHODS: 60 patients with hypertension, diabetes and dyslipidemia on treatment for 1-2 years were recruited and randomized into two groups to receive either Standard treatment alone or Tab.Vitamin C 500mg OD and Cap.Vitamin E 400mg OD along with standard treatment for 8weeks. They are followed up for 4weeks post treatment. RBC morphology changes, Blood pressure, Fasting blood sugar, Lipid profile were assessed at 0, 4, 8 and 12 weeks. RESULTS: Baseline characteristics were similar in both groups. At the end of 8 weeks study group showed significant reduction in Total cholesterol (p<0.001), LDL (p=0.001), Fasting blood sugar (p=0.023), Systolic blood pressure (p=0.024) and Diastolic blood pressure (p=0.005), percentage of crenated RBCs with Heinz bodies (p<0.001) and increase in HDL (p=0.03) compared to control group. Hemoglobin and RBC counts were also increased in the study group. Minimal adverse effects were observed in both the groups. CONCLUSION: Vitamin C and E as add on therapy to the standard treatment is effective in reducing Insulin resistance, Blood pressure and improving lipid profile. The Hemolytic anemia improved significantly following antioxidant treatment proves the fact that oxidative stress and chronic inflammation causes damage to RBCs.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.201416002 |
| Uncontrolled Keywords: | Metabolic Syndrome, Psychological Stress, Oxidative Stress, Antioxidants, Vitamin E and Vitamin C, Nitric oxide, Inflammation, Hemolytic anemia. |
| Subjects: | MEDICAL > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 18 Jul 2020 18:22 |
| Last Modified: | 19 Jul 2020 12:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12566 |
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