CD 105 (Endoglin) Expression in Oral Squamous Cell Carcinoma

Srimahalakshmi, A (2017) CD 105 (Endoglin) Expression in Oral Squamous Cell Carcinoma. Masters thesis, Stanley Medical College, Chennai.


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BACKGROUND: Increasing evidence suggests that angiogenesis is an essential factor in the tumour growth, invasion and metastasis. Research on related parameters such as micro vessel density could be helpful in predicting the tumour behavior. Recently, Endoglin (CD105) has been introduced as a new powerful marker of neoangiogenesis that stains vessels in the proliferating stage. Many studies revealed that Endoglin (CD105) was intensively expressed in the tumour vessels and therefore could be both predictive and prognostic marker for the outcome in various malignancies. AIMS AND OBJECTIVES: To determine and correlate the Endoglin (CD105) expression in normal oral mucosa, pre malignant lesions of oral cavity and in oral squamous cell carcinoma. MATERIALS AND METHODS: Thirty (30) cases of normal oral mucosa, thirty (30) cases of oral pre-malignant lesions and thirty (30) histopathologically confirmed cases of oral squamous cell carcinoma, were immunohistochemically analyzed for Endoglin (CD105) expression and quantitated by evaluating micro vessel density through “Hot spot method”. RESULTS: There was a significantly (P value <0.001) higher expression of Endoglin in oral squamous cell carcinoma than that of normal oral mucosa and pre malignant lesions. Among carcinoma, Endoglin expression was significantly (P value 0.005) higher in poorly differentiated carcinoma when compared to well and moderately differentiated carcinoma. There was no association with this Endoglin expression and patients age, gender or tumour localization. CONCLUSION: The finding of significantly higher MVD score in carcinoma than in normal oral mucosa and in pre malignant lesions make us to emphasize that Endoglin could be a useful predictive and prognostic marker of malignancy.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201413052
Uncontrolled Keywords: Endoglin, CD105, Microvessel density, oral squamous cell carcinoma, oral dysplasia.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 18 Jul 2020 16:34
Last Modified: 18 Jul 2020 16:34

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