A Study on Immuno-Histochemical Expression of C-Kit in Invasive Breast Carcinoma and Its Clinicopathological Correlation

Lavanya, N (2017) A Study on Immuno-Histochemical Expression of C-Kit in Invasive Breast Carcinoma and Its Clinicopathological Correlation. Masters thesis, Madras Medical College, Chennai.


Download (8MB) | Preview


INTRODUCTION: Breast carcinoma is the most common malignant tumor and also one of the leading cause of carcinoma deaths in women. There are many prognostic factors established for breast carcinoma. C-kit is a proto-oncogene, that has a role in the pathogenesis of preinvasive and invasive breast cancer and more among Triple negative cancers. Pattern of expression of c-kit and correlation of clinico-pathological parameters are studied. MATERIALS AND METHODS: A total of 165 breast carcinoma specimens (Mastectomy) were enrolled between the period of September 2014 to August 2016. Age, side of breast, tumor location, tumor size, lymph node involvement, lymphocytic response, skin infiltration and ER, PR, HER2neu receptors status were analyzed. Among the 165 cases, 50 cases (42 infiltrating ductal carcinoma NOS, 8 special subtypes) were evaluated for ckit expression pattern using Rabbit Polyclonal Antibody (Pathnsitu) and its correlation with above mentioned parameters were studied. RESULTS: Median age of the study group is 49 years. IDC NOS is the commonest type, 56.4% are Grade 2 tumors. Node positive cases are 58.25% (n=96). C-kit is expressed in 40% of the cases (n=20 out of 50). Loss of c-kit expression is associated with high grade tumors. Special subtypes except Metaplastic carcinoma showed 100% expression. Eleven out of 18 cases of DCIS showed c-kit positivity. Normal Breast epithelium showed 100% positivity. Triple negative tumors showed more positivity. CONCLUSION: C-kit expression decreases on tumor progression from normal epithelium and it is associated with high grade tumors and triple negative breast cancers. This study may suggest, c-kit has a definitive role in the pathogenesis of breast cancer and this could be used as a prognostic marker and can be used for targeted therapy in triple negative breast carcinomas.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201413006
Uncontrolled Keywords: C-kit, Triple negative breast cancer, Infiltrating ductal carcinoma.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 18 Jul 2020 15:57
Last Modified: 18 Jul 2020 15:57
URI: http://repository-tnmgrmu.ac.in/id/eprint/12527

Actions (login required)

View Item View Item