Diagnostic application of expression of CD 56 Immunohistochemistry Marker in Papillary Carcinoma of Thyroid

Kavipriya Rajendran, (2017) Diagnostic application of expression of CD 56 Immunohistochemistry Marker in Papillary Carcinoma of Thyroid. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND: Thyroid cancer is the most common malignant endocrine tumor. Currently, tissue biopsy and pathological assessment are the best diagnostic modalities for thyroid lesions. Papillary carcinoma of the thyroid is the commonest thyroid cancer. In the recent decades an increase in the incidence of papillary carcinoma has been documented. The pathological diagnosis of PTC is fairly simple in the majority of cases. However, with the introduction of follicular variant of PTC and the wide threshold range in interpretation of pathological criteria for diagnosis of PTC, the diagnosis in few cases became quite difficult. Unfortunately, some cases are unjustifiably over-called as follicular variant of PTC due to the wide inter observable variability. It becomes exceedingly important to differentiate as management and prognosis of a patient varies with benign and malignant lesions. AIMS AND OBJECTIVES: To study the expression of CD 56 marker on various thyroid pathologies and analyse the significance of CD 56 marker expression on papillary carcinoma of thyroid and its variants in differentiating from benign follicular thyroid neoplasm. MATERIALS AND METHODS: 58 paraffin section blocks of thyroidectomy specimen were selected based on the H&E stained slide diagnosis reported by senior pathologists. CD 56 marker was applied to these cases and their expression was assessed. RESULTS: Statistical analysis showed significantly different expressions of CD56 in Papillary carcinoma versus other lesions of the thyroid gland. The sensitivity and specificity of CD56 for diagnosing Papillary carcinoma were 86.7% and 85.7%, respectively with a diagnostic accuracy of 86.2%. CONCLUSION: CD56 is both a sensitive and specific marker for differentiating Papillary carcinoma from other follicular lesions of thyroid singly but it may be better to use a combination of markers for clinical evaluation of patients.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201413005
Uncontrolled Keywords: Thyroid malignany, CD 56, Papillary carcinoma.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 18 Jul 2020 15:51
Last Modified: 18 Jul 2020 15:51
URI: http://repository-tnmgrmu.ac.in/id/eprint/12526

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