Jayakarthiga, S R (2017) A Study on immunohistochemical expression of CD163 in tumour cells and tumour-associated macrophage infiltration in colorectal carcinoma and clinicopathological corelation. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Colorectal carcinoma is one of the most common malignancy worldwide. Tumour microenvironment plays an important role in malignant disease progression. Monocytes are actively recruited to the tumour stroma. There are two polarization states in macrophages. M1-proinflammatory and M2 are immunosuppressive. Tumour-associated macrophages are M2 macrophages which play a role in tumour invasion and metastasis. CD163 – a macrophage specific marker expressed predominantly by M2 macrophage. AIMS AND OBJECTIVES: This study was conducted to evaluate the expression of CD163 in colorectal tumour cells and their relationship with Tumour-associated macrophage infiltration and their clinicopathological correlation. MATERIALS AND METHODS: 95 cases of colorectal resection specimens were received during the study period (September 2014 to September 2016). 50 random cases were selected among them and CD163 expression and tumour-associated macrophage infiltration were evaluated.CD163 expression and tumour-associated macrophage infiltration were assessed in grades. OBSERVATION AND RESULTS: Out of 50 cases, 8 (16%) showed CD163 positivity. 74% and 26% showed low and high grad of tumour-associated macrophage infiltration. The relationship between CD163 expression and tumour-associated macrophage infiltration was statistically significant (p0.001). The relation between lymphatic invasion (p=0.004), lymphnode metastases (p=0.021), advanced MAC-Modified Astler-Coller stage (p=0.005) with CD163 expression was statistically significant. The relation between lymphatic invasion (p=0.004), lymphnode metastasis (p=0.024), advanced MAC stage (p=0.002) was statistically significant. CONCLUSION: Expression of CD163 expression as a macrophage trait in cancer cells has a significant association with high grade of tumour-associated macrophage infiltration, lymphnodal metastases and advanced stage. Anti CSF-1R (RG7155) which targets the tumour associated macrophages will be helpful in the targeted therapy in the future.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201413003 |
| Uncontrolled Keywords: | Colorectal carcinoma, CD163, tumour-associated macrophage, advanced MAC stage. |
| Subjects: | MEDICAL > Pathology |
| Depositing User: | Subramani R |
| Date Deposited: | 18 Jul 2020 14:55 |
| Last Modified: | 18 Jul 2020 14:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12524 |
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