Janani, Vasudevan (2012) D2-40 Positive Lymphatic Vasculature in Oral Squamous Cell Carcinoma (OSCC): An Immunohistochemical study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
This immunohistochemical study comprised of a total of thirty five subjects in three groups: ten in metastatic OSCC (Group 1), fifteen in non metastatic OSCC (Group 2) and ten in control group (Group 3). D2-40 monoclonal antibody against lymphatic endothelial cells was used to study the lymphatic vessel density between the 3 groups. The conclusions of the study are: • D2-40 positivity is specific to lymphatic endothelial cells and absent in endothelial cells of blood vessels. • Lymphatic vessel density is higher in non metastatic OSCC group when compared to the control group (p=0.001). • Lymphatic vessel density is higher in the metastatic OSCC group when compared to the normal group (p=0.000). • Lymphatic vessel density is higher in the metastatic OSCC group when compared to non metastatic OSCC group (p=0.001). • Lymphatic vessel density is higher in metastatic OSCC group than non metastatic OSCC group which is in turn higher than the control group (p=0.000). • Lymphatic vessel density is higher, but not statistically significant in poorly differentiated and moderately differentiated OSCC when compared to well differentiated OSCC. • D2-40 stained the basal layer of the surface epithelium having. • sub epithelial inflammatory cell infiltrate and those adjacent to tumor islands. • D2-40 immunoreactivity was diffuse in poorly and moderately differentiated OSCC. It was restricted to the basal cells in well differentiated OSCC. Our results indicate that D2-40 has the potential to be a surrogate marker of OSCC aggressiveness because lymphatic vessel density and D2-40 positive reaction in cancer cells were associated with lymphatic vessel density. Thus, staining with D2-40 may be important in determining the prognosis of OSCC.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | D2-40 Positive Lymphatic Vasculature, Oral Squamous Cell Carcinoma (OSCC), Immunohistochemical study. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Mar 2020 03:09 |
| Last Modified: | 24 Mar 2020 03:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12445 |
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