Femina Kokila, V (2012) CD-34 Positive Vasculature in Oral Squamous Cell Carcinoma (OSCC): An Immunohistochemical study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
Tumors require blood supply for their growth and dissemination. Angiogenesis is a complex process and there is evidence that it is closely linked to cell proliferation and apoptosis, thus representing a critical step for tumor formation and progression. It is a well accepted paradigm that tumors recruit new blood vessels from the existing circulation (angiogenesis) and participates in tumor invasion and metastases. The number of vessels per unit area of tumor tissue is denoted by microvascular density. This immunohistochemical study comprised of a total of 35 subjects in three groups: ten metastatic OSCC (Group 1), fifteen non metastatic OSCC (Group 2) and ten control group (Group 3). CD 34 antibody against vascular endothelial cells was used to study the microvascular density between the three groups. The conclusions from the study are: • CD 34 positivity is observed in the endothelial cells of blood vessels and lymphatic vessels. • There is no difference in microvascular density between the control group and the non metastatic OSCC group. (p=1) • Microvascular density is higher in the metastatic OSCC group when compared to the normal group (p=0.003). • Microvascular density is higher in the metastatic OSCC group when compared to the non metastatic OSCC (p=0.000) • Microvascular density is higher in the peritumoral areas than in the intratumoral areas. Our results indicate that CD 34 is a potential marker to predict OSCC invasiveness and metastasis and staining with CD 34 may be useful in determining the prognosis of OSCC.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | CD-34 Positive Vasculature, Oral Squamous Cell Carcinoma (OSCC), An Immunohistochemical study. |
| Subjects: | DENTAL > Oral Pathology and Microbiology |
| Depositing User: | Subramani R |
| Date Deposited: | 24 Mar 2020 02:58 |
| Last Modified: | 24 Mar 2020 02:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12444 |
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