Timothy Chelliah, S (2014) MRI spectrum of cerebral palsy in correlation with clinical profile. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: To describe MRI brain spectrum in a group of Cerebral Palsy children and correlate with perinatal history, clinical subgroups. To correlate callosal thinning with topographies and periventricular leukomalacia grades. METHODS: IRB approved observational study (cross sectional study) on CP children in between the period March 2012-October 2013 in Christian Medical College, Vellore. The important MRI features described are periventricular leukomalacia (PVL), deep gray nuclei involvement, cystic encephalomalacia, arterial territory infarcts, corpus callosal thinning, perirolandic cortical gliosis and malformations. These were correlated with the relevant perinatal history and clinical subgroups by cross tabulation and Chi square tests. RESULTS: A set of specific MRI features can be seen in different clinical pictures and a particular clinical picture can have varied MRI findings. Higher grades of PVL are associated with higher degree of neurological deficit and higher grades of thinning of corpus callosum. Deep gray nucleus signal abnormalities are seen significantly with combination of neonatal hyperbilirubinemia and birth asphyxia. Dystonic cerebral palsy is strongly associated with the deep gray nuclei involvement. Callosal thinning may be an isolated finding in CP; hence an important pick up.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Cerebral palsy, MRI brain, periventricular leukomalacia, corpus callosum, arterial territory infarcts, corpus callosal thinning, malformations, deep grey nuclei, hyperbilirubinemia, birth asphyxia, topography, preterm and term. |
| Subjects: | MEDICAL > Radio Diagnosis |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Mar 2020 15:54 |
| Last Modified: | 23 Mar 2020 15:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12423 |
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