Jeba Karunya, Ramireddy (2014) A Pilot study to evaluate the feasibility, tolerance and efficacy of addition of hyperthermia to external beam radiotherapy (EBRT) on patients with locally advanced non metastatic inoperable head and neck cancer for palliation of symptoms. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: To assess the feasibility and toxicity of hyperthermia with radiation in patients with locally advanced non metastatic head and neck cancers, to assess the palliation of distressing symptoms in them. METHODS: Ten patients diagnosed to have locally advanced head and neck cancers, were treated with radiotherapy to a dose of 66 Gy in 33 fractions in Cobalt 60 machine(conventional fractionation) along with once weekly sittings of hyperthermia. Hyperthermia was given 30 minutes before radiotherapy for 30 minutes. Descriptive statistics was done. Weekly toxicity was monitored by RTOG and CTCAE criteria. Pain and quality of life (EORTC questionnaire)) was assessed before and after treatment. Response was compared with CT scans 3 months after treatment with Wilcoxan sign test. Response was assessed by RECIST criteria. Survival analysis was done by Kaplan meier method. RESULTS: Among the 10 patients, 6 (60%) completed the treatment and 3(30%) without break. The incidence of grade 3 mucositis, grade 4 mucositis and grade 3 dermatitis was 42%, 14% and 28% respectively. The mean reduction in nodal size was 70% at 6 weeks. Pain control was good for a short duration (2 months), after which 50% of patients required STEP 3 analgesics. CONCLUSION: This treatment can be considered in patients with large, fixed nodes. Hyperthermia should be carried out with planned infrastructure and meticulous temperature monitoring and dosimetry.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Head and neck cancers, Hyperthermia, radiotherapy, palliation. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Mar 2020 15:25 |
| Last Modified: | 23 Mar 2020 15:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12418 |
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