A study on the expression of cox-2 (cyclooxygenase-2) and p16 in squamous cell carcinoma of the oral cavity and upper respiratory tract.

Kanimozhi, S (2016) A study on the expression of cox-2 (cyclooxygenase-2) and p16 in squamous cell carcinoma of the oral cavity and upper respiratory tract. Masters thesis, Madras Medical College, Chennai.

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Abstract

Squamous cell carcinoma (SCC) of the oral cavity and upper respiratory tract ranks as the sixth leading cause of cancer worldwide. This represents about 4% of all cancers. Among the oral and upper respiratory tract malignancies, squamous cell carcinoma comprises more than 90%. With Immunohistochemical analysis, the percentage of COX-2 and p16 expression were noted in a significant number of cases. This finding had led some researchers to recommend HPV vaccine in the prevention of squamous cell carcinoma of head and neck. Expression of COX-2 is associated with high metastatic potential of the tumor because of increased microvessel density and lymphangiogenesis. COX-2 expression is also associated with resistance to chemoradiation. This led to the focus on combined treatment modality like chemoradiation with targeted therapy to improve the response to therapy, thereby increasing the survivability of the patient.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Squamous Cell carcinoma ; Oral Cavity ; Upper Respiratory Tract ; COX-2 ; p16.
Subjects: MEDICAL > Pathology
Depositing User: Punitha K
Date Deposited: 07 Jul 2017 11:49
Last Modified: 08 Nov 2018 07:49
URI: http://repository-tnmgrmu.ac.in/id/eprint/1240

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