A Prospective study to compare the efficacy of Recombinant Epidermal growth factor in Wound Healing with Normal Saline Dressing

Felix Cordelia, M J (2017) A Prospective study to compare the efficacy of Recombinant Epidermal growth factor in Wound Healing with Normal Saline Dressing. Masters thesis, Madras Medical College, Chennai.


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BACKGROUND AND OBJECTIVE: Ulcers are a cause of morbid illness prolonging the hospital stay of patients for want of utmost care in order to avoid amputations. Various advanced treatment modalities are being available these days to reduce the morbidity and quicken the process of healing. One such readily available product is the Human Recombinant Epidermal Growth Factor which has proven efficacy in increasing the healing rate. This study is aimed at comparing the efficacy of rhEGF (available in the brand name REGEN D 150) to normal saline dressings in improving the healing rate of large ulcers. METHODS: Between March 2016 and September 2016, 104 patients with ulcers who got admitted to Institute of General Surgery, Rajiv Gandhi Government General Hospital, Chennai were recruited to the study by randomising them to test and control groups. The study ended with 100 patients, 50 in each group and both the systems were compared. The effects of rhEGF on wound healing were analysed and compared to that of the conventional normal saline dressing. RESULTS: The study group dressed with rhEGF showed a significant reduction in size of the ulcers irrespective of other comorbidities or sites of ulcer. The healing rate was calculated as percentage reduction in size per week and the significance was analysed. Further analysis was done on the infectivity rate of ulcers in each group and found that rhEGF significantly prevents ulcers from micro organism colonisation. INTERPRETATION AND CONCLUSION: The efficacy of rhEGF in ulcer healing as analysed in many studies was found to be higher than the usual conventional normal saline dressing and this effect was statistically significant. Large ulcers treated with rhEGF showed an increased healing rate and ulcer was made ready for skin grafting sooner than usual thus avoiding unnecessary amputations.

Item Type: Thesis (Masters)
Uncontrolled Keywords: ulcers, wound healing, growth factors, rhEGF, normal saline, wound dressing, diabetes, infection, antibiotics.
Subjects: MEDICAL > General Surgery
Depositing User: Devi S
Date Deposited: 18 Mar 2020 17:56
Last Modified: 18 Mar 2020 17:56
URI: http://repository-tnmgrmu.ac.in/id/eprint/12340

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