Expression of Cycloxygenase-2 in Cervical Carcinoma and Its Correlation with Clinicopathological Variables

Divya, N (2016) Expression of Cycloxygenase-2 in Cervical Carcinoma and Its Correlation with Clinicopathological Variables. Masters thesis, Madras Medical College, Chennai.

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Abstract

Cervical carcinoma ranks fourth among the leading causes of cancer worldwide, after carcinoma of breast, colorectal carcinoma and lung carcinoma. In developing countries like India, cervical carcinoma accounts for the second most common cancer occurring in women and also the second leading cancer killer next only to carcinoma breast. There are many well established prognostic factors for carcinoma of cervix including FIGO stage, HPV status, age of the patient, tumor size, depth of stromal invasion, nodal status, parametrial involvement, lymphovascular invasion etc. Recently, several biomarkers were studied which may have a role in predicting the prognosis and also in the selection of therapeutic strategies that can be helpful to further improve patient survival for carcinoma of cervix. Of these one important molecular marker is cycloxygenase 2 (COX2). In our study, we evaluate thepattern of COX-2expression in cervical carcinomas and its association with various clinicopathological variables like age of the patient, stage, menstrual status, tumor size, parametrial involvement, vaginal involvement, nodal status and histological grade of tumor. AIMS AND OBJECTIVES: To assess the expression of Cycloxygenase 2 (COX-2) in invasive cervical carcinomas. To compare the clinical behaviour of cervical carcinomas and cyclooxygenase 2 expression. To correlate the expression of cyclooxygenase -2 (COX2) with various clinicopathological variables. To assess the value of COX2 as a prognostic and predictive marker. MATERIALS AND METHODS: For the 50 patients included in the study, the paraffin tissue blocks were cut and stained with eosin and hematoxylin.Immunohistochemical analysis of marker COX2 was done in all these cases and the results compared with the clinical and morphological parameters to study the efficiency of marker (COX2). RESULTS: When the menstrual status and stage of the disease were compared, it was noted that menstruating females presented in early stages of the disease, whereas postmenopausal females presented in advanced stages of disease. This correlation was statistically found to be significant with a p value of 0.004. In our study, it was noted that smaller tumors showed less COX2 expression whereas it was significantly higher for larger tumors. This was found to be statistically significant with a p value of 0.007. On comparing the COX2 expression with nodal status of the patients, it was noted that among cases with enlarged nodes, 44.2% had positive COX2 expression. This was found to be statistically significant with a p value of 0.026. On comparing COX2 expression with clinical stage of the disease, it was noted that COX2 expression was more in tumors of higher clinical stage. CONCLUSION: In our study, expression of COX2 was found to be correlating with many of the established poor prognostic factors. Hence it can be concluded that this study is pointingtowards the possibility of considering COX2 as a poor prognostic marker for cervix carcinoma.

Item Type: Thesis (Masters)
Uncontrolled Keywords: COX2 ; FIGO ; HPV ; cervix carcinoma.
Subjects: MEDICAL > Pathology
Depositing User: Laksham S
Date Deposited: 07 Jul 2017 09:39
Last Modified: 23 May 2018 02:32
URI: http://repository-tnmgrmu.ac.in/id/eprint/1230

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