Vinod Joshua John, (2014) Efficacy of Mitomycin C in External Dacryocystorhinostomy: A Randomised Control trial. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: The aim of this study is to compare the success rates of External Dacryocystorhinostomy (Ext-DCR) with and without the intraoperative application of Mitomycin C (MMC) at the ostium site. METHODS: 60 cases of Primary Acquired Nasolacrimal Duct Obstruction (PANDO) which met the inclusion criteria were randomized into 2 groups of 30 each.The MMC group received 0.4ml/mg of MMC intraoperatively at the ostium site while the Control group was given normal saline as placebo.The outcomes measured were subjective symptomatic grading by Muck scoring system,functional success by Fluorescene Dye Disappearance Test (FDDT) and anatomical duct patency by syringing at 1week,1 month and 3 month follow up. RESULTS: There was female preponderance with 78.3%. There was no statistically significant difference in the subjective, functional and anatomical success rates between the 2 groups at 1 week,1 month and 3 month follow up (p > 0.1). The overall success rate was 96.7% in MMC group and 93.35 in Controls (p = 0.546). There were no serious adverse effects seen with MMC use. We conclude that Mitomycin C application may not show an added in Primary External DCR for Primary Adult Nasolacrimal Obstruction.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.221213307 |
| Uncontrolled Keywords: | epiphora, nasolacrimal duct obstruction, external dacryosystorhinostomy, mitomycin C. |
| Subjects: | MEDICAL > Ophthalmology |
| Depositing User: | Devi S |
| Date Deposited: | 15 Mar 2020 12:14 |
| Last Modified: | 15 Mar 2020 12:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12277 |
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