To Study the Combined use of Pleural Fluid Lymphocyte / Neutrophil Ratio and Ada for the Diagnosis of Tuberculous Pleural Effusion

Suresh, R (2017) To Study the Combined use of Pleural Fluid Lymphocyte / Neutrophil Ratio and Ada for the Diagnosis of Tuberculous Pleural Effusion. Masters thesis, Madurai Medical College, Madurai.

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Abstract

AIMS AND OBJECTIVES: To determine whether the combined use of ADA activity and lymphocyte/neutrophil ratio would provide a more efficient means for diagnosing tuberculouspleural effusion than with the use of ADA alone. MATERIALS AND METHODS: Design of Study: Hospital based prospective observational study. Period of Study: February 2016 to July 2016. Study Method: 1. All the patients with pleural effusion admitted in medical ward at GRH Madurai. 2. Information collected through preformed and pretested proforma. 3. The qualifying patients will be undergoing detail history, clinical examination and investigation. 4. Patients will be classified as exudative and transudativepleural effusion based on light’s criteria. LIGHT’S CRITERIA: 1. Pleural fluid / serum protein ratio > 0.5, 2. Pleural fluid LDH / serum LDH ratio > 0.6, 3. Pleural fluid LDH > 2/3 of upper normal value of serum. •Exudative causes: 1. TB, 2. Bacterial, viral, fungal, parasitic infection, 3. Collages vascular disease, 4. Neoplasms, 5. Pulmonary embolism, 6. Meig’ssyndrome, 7. Uremia, 8. GI causes. INCLUSION AND EXCLUSION CRITERIA: Inclusion criteria: all exudative pleural effusion cases Exclusion criteria: Patients with transudativepleural effusion, Patients with immunodeficient states like HIV, those on chemotherapy. TB PLEURAL EFFUSION: -The pleural fluid ADA > 50. -The pleural fluid L/N ratio > 0.75. -will be taken as positive for tuberculouspleural effusion. •Other effusions: The pleural fluid ADA >50, The pleural fluid L/N ratio <0.75, CONCLUSION: The combined use of ADA along with L/N ratio would provide a more efficient means for diagnosing tuberculousPleural effusion than the use of ADA alone.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Pleural Fluid Lymphocyte, Neutrophil Ratio, Ada for the Diagnosis, Tuberculous Pleural Effusion.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 12 Mar 2020 17:36
Last Modified: 12 Mar 2020 17:36
URI: http://repository-tnmgrmu.ac.in/id/eprint/12242

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