A Study of Expression of Thyroid Transcription Factor (ttf-1) in Endometrial Adenocarcinoma of Uterine Corpus.

Brinda, M (2016) A Study of Expression of Thyroid Transcription Factor (ttf-1) in Endometrial Adenocarcinoma of Uterine Corpus. Masters thesis, Madras Medical College, Chennai.


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Among females endometrial carcinoma is the most frequent malignancy worldwide. It is the second most frequent malignancy of gynecological tract in developing nations having an incidence of approximately six cases per one lakh population. Thyroid transcription factor is a Deoxy ribonuclease protein determined by the gene placed on chromosome 14q13.It has been regarded as a specific and sensitive marker for tumors arising in thyroid and lung. This study is undertaken to probe Thyroid transcription factor positivity in primary uterine endometrial adenocarcinoma and also in malignant mixed mullerian tumour. AIMS AND OBJECTIVES: To study the incidence and distribution of Thyroid transcription factor in endometrial adenocarcinoma. To correlate the percentage of expression of TTF-1 with the grade of endometrial adenocarcinoma .And to assess the prognosis based on the expression of TTF-1 for the patients who were on follow up. MATERIALS AND METHODS: 93 cases Paraffin sections of hysterectomy specimens diagnosed as Endometrial carcinoma will be subjected to routine H&Estaining and IHC marker TTF1 was done for 50 random cases. RESULTS: Among 50 randomly selected cases TTF 1 marker was done ,only 3 cases showed positivity for TTF 1. Two cases of moderately differentiated endometrioid carcinoma were focally positive and one case of poorly differentiated carcinoma was diffusely positive for TTF 1, all others were negative. The relationship between TTF 1 positivity and grade of endometrioid carcinoma has a pvalue of 0.004 which is statistically significant. CONCLUSION: In our study the incidence of different types of endometrial carcinoma in the 5 years from January 2010 to December 2014 in the Institute of Obstetrics and Gynecology, Madras Medical College, Chennai was studied. This study confirms that TTF 1 positivity correlates with grade of endometrial carcinoma. Out of the 3 positive cases, the follow up for 7 months was available for only case of stage I low grade endometrioid carcinoma and the comment on prognosis can only be made on long term followup.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Thyroid Transcription Factor (ttf-1) ; Endometrial Adenocarcinoma ; Uterine Corpus.
Subjects: MEDICAL > Pathology
Depositing User: Laksham S
Date Deposited: 07 Jul 2017 07:53
Last Modified: 23 May 2018 02:24
URI: http://repository-tnmgrmu.ac.in/id/eprint/1223

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