A study on clinico pathological correlation of HER2 positivity in Gastric Malignancy

Thirumal, P (2014) A study on clinico pathological correlation of HER2 positivity in Gastric Malignancy. Masters thesis, Kilpauk Medical College, Chennai.


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INTRODUCTION: Gastric cancer show varying clinical behaviour and response to chemotherapy, determined by biological aberrations and molecular vulnerabilities to chemotherapy drugs. Overexpression of Human epidermal growth factor receptor (HER2, also known neu, ERBB2) is associated with poor prognosis, aggressive disease and poor response to chemotherapy . AIM OF THE STUDY: To study the frequency of HER2 positivity in gastric and oesophagogastric junction (OGJn) cancer and its correlation with clinical and pathological variables. Place of Study: Department of Digestive Health and Diseases, Government Peripheral Hospital, Anna Nagar, Chennai MATERIALS AND METHODOLOGY: Patients with diagnosed gastric and oesophagogastric adenocarcinoma were being enrolled from June 2013 to February 2014.Endoscopic biopsy specimen was studied for HER2 overexpression using Immunohistochemistry(IHC) with score of 3+ considered positive.HER2 positivity was correlated with clinicopathological variables. RESULTS: A total of 61 patients (53 male & 8 female) were taken for study analysis. 60 patients had distal gastric cancer and one patient had proximal cancer. Majority of patients (74.4%) at time of diagnosis were in advanced stage of disease. HER2 positivity was observed in 34.4% (21 patients) of our study population. There was no correlation of HER2 overexpression with age or gender. A statistically significance (p = 0.0003) correlation was present between HER2 positivity and advanced stage of cancer.HER2 overexpression was more in intestinal type than diffuse type adenocarcinoma. During the 8 month follow up among HER2 positive patients, none had curative resection and only 2 out of 21 patients survived. CONCLUSION: HER2 overexpression is positively correlated with advanced stage of gastric cancer and this subgroup of patient seems to have poor survival outcome. Hence, HER2 testing may be considered as part of routine work up in gastric cancer patients to prognosticate the survival outcome.

Item Type: Thesis (Masters)
Additional Information: Reg.No.16112656
Uncontrolled Keywords: Gastric cancer, HER2 overexpression, survival outcome.
Subjects: MEDICAL > Gastroenterology
Depositing User: Subramani R
Date Deposited: 07 Mar 2020 04:31
Last Modified: 07 Mar 2020 04:31
URI: http://repository-tnmgrmu.ac.in/id/eprint/12160

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