Formulation and Evaluation of Biodegradable Implantable Drug Delivery System of Clindamycin Hydrochloride

Beetha Rohini, S (2012) Formulation and Evaluation of Biodegradable Implantable Drug Delivery System of Clindamycin Hydrochloride. Masters thesis, R V S College of Pharmaceutical Sciences, Coimbatore.

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Abstract

The purpose of this study is to formulate implant containing Clindamycin hydrochloride that could be used in the treatment of periodontitis. The implants were formulated by using biodegradable polymer, gelatin and sodium alginate with PEG 400 as a plasticizer. The drug and polymer compatability in implants were studied by FT-IR and DSC. There was no interaction between the drug and polymer. The implant was evaluated for physicochemical properties such as weight uniformity, thickness, content uniformity, %moisture loss and surface pH. The result of physicochemical properties was uniform for all the formulations. The in-vitro results showed that increase in the polymer concentration (70:30) prolong the drug release upto 24hrs. Optimized formulation F7 release 84.90% of drug at the end of 24th hr and considered as a best formulation. The release mechanism for invitro release was studied by using various mathematical models. The ‘n’ value for the koresmeyer-peppas equation was in the range of 0.87-0.98 indicating the anamolous behaviour (non-fickian release). In-vitro antibacterial activity was carried out in Staphylococcus aureus and Enterobacter aerogen had an inhibitory effect after 24hrs of incubation. The stability studies were carried out at room temperature, dark place and direct sunlight which does not shows any significant change after one month.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation ; Evaluation ; Biodegradable Implantable Drug ; Delivery System ; Clindamycin Hydrochloride.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 07 Jul 2017 05:31
Last Modified: 15 May 2018 23:45
URI: http://repository-tnmgrmu.ac.in/id/eprint/1213

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