Brahmini, A (2012) Comparitive Stability Studies on Rifampicin in Fixed Dose Combinations Between Blister and Strip Packaged Marketed Products. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode.
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Abstract
Tuberculosis is a ubiquitous, highly contagious chronic granulomatous bacterial infection caused by the Mycobacterium tuberculosis. Mycobacterium tuberculosis is rod shaped bacteria called as Koch’s bacillus. Tuberculosis is the world’s commonest cause for death after HIV/AIDS. According to WHO about 1/3rd of world population are infected with TB. More than 8 million people are commonly infected with TB annually in developing countries like sub- Saharan Africa and Asia.1 The prevalence of TB in India accounts for 30% of global burden and when combined with cases from china constitute 40% of all cases globally. Approximately 10% of the infected people develop active TB. A salient finding of this study is fixed dose combinations containing rifampicin, isoniazid, pyrazinamide and ethambutol stored in freezer (40C) showed less amount of degradation of rifampicin when compared to other temperatures like 300C and 400C with 75%RH. This study showed that strip package undergo less degradation when compared to blister package because strip packages show low moisture gain while blister package show high moisture gain. Therefore manufacturers should use packaging materials that provide strong barriers
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Rifampicin ; Fixed Dose ; Blister ; Strip Packaged Marketed Products. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 07 Jul 2017 05:07 |
| Last Modified: | 15 May 2018 23:49 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1211 |
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