Dinesh, S (2012) Formulation and Evaluation of Cinitapride Tablets as Floating Drug Delivery System. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.
|
Text
DINESH S.pdf Download (1MB) | Preview |
Abstract
Oral administration is the most convenient and preferred means of any drug Delivery to the systemic circulation. Oral controlled release drug delivery have Recently been of increasing interest in pharmaceutical field to achieve improved Therapeutic advantages, such as ease of dosing administration, patient compliance And flexibility in formulation. Drugs that are easily absorbed from gastrointestinal Tract (git) and have short half-lives are eliminated quickly from the systemic Circulation. Frequent dosing of these drugs is required to achieve suitable Therapeutic activity. To avoid this limitation, the development of oral sustainedcontrolled Release formulations is an attempt to release the drug slowly into the Gastrointestinal tract (git) and maintain an effective drug concentration in the Systemic circulation for a long time. In the present work floating tablets have been prepared incorporating a Highly soluble anti-ulcer drug cinitapride using polymers like (hpmc K4m,hpmc e15m and hpmc k100m). Swelling agent (carbapol 940) was used To keep the tablets floating over the simulated gastric fluid (ph 1.2) for more Than 12 hrs. All the formulations showed floating lag time less than 5 min. Microcrystalline cellulose is used as a filler. The drug release mechanisms for These formulations were confirmed as zero-order release. The formulations (f5) Were selected as an optimized formulations because it gave the best results in Terms of the required in-vitro buoyancy as well as drug release in a sustained Release manner and also were found to be stable under the stability conditions. Thus the results of the current study clearly indicate, a promising potential of the Floating tablet as an alternative to conventional dosage form, further clinical Studies are needed to assess the utility of this system for patients suffering from Gastro-esophageal reflux disease, non-ulcer dyspepsia.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Formulation ; Evaluation ; Cinitapride Tablets ; Floating Drug Delivery System. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 07 Jul 2017 03:51 |
| Last Modified: | 16 May 2018 00:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1209 |
Actions (login required)
 |
View Item |
