Sunil Kumar, T (2011) Association between Microalbuminuria and Risk Factors and complications among patients with Type II Diabetes Mellitus. Masters thesis, PSG Institute of Medical Sciences and Research, Coimbatore.
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Abstract
INTRODUCTION: Diabetes mellitus, the most common endocrine disorder is characterised by metabolic abnormalities and long-term microvascular and macrovascular complications. The prevalence of diabetes is on the rise, more alarming in the developing countries. Besides multiplying risk for coronary heart disease, diabetes enhances the incidences of cerebrovascular accidents. Moreover it is the leading cause of acquired blindness and accounts for about a quarter of the cases with end stage renal disease as well as half of the cases of non-traumatic lower limb amputations. OBJECTIVES: To find the association between microalbuminuria and its risk factors and complications in south Indian type II Diabetes population attending PSGIMS&R, Peelamedu, Coimbatore. MATERIALS AND METHODS: One hundred patients of Type II DM admitted to PSGIMS & R were studied. The patients were taken from both IP and OP of the hospital, based on random selection. Patients were considered to be diabetic based on WHO (2) criteria for diagnosis of diabetes mellitus which is : - 1) Symptoms of diabetes mellitus plus a random glucose concentration >200 (11.1mmol/l). The classic symptoms of diabetes mellitus include polyuria, polydipsia and unexplained weight loss OR 2) Fasting blood glucose >126 mg/dl (7.0mmol/l). Fasting is defined as no caloric intake for at least 8 hours OR 3) 2 hour post prandial glucose > 200mg/dl (11.1 mmol/l). Among diabetics, the above criteria were considered to include the patients for the study. OR 4)HbA1C> 6.5. Inclusion criteria for case selection: 1) Urine sugar – positive. 2) Fasting blood sugar > 126 mg/dl. Exclusion criteria for case selection: 1) Patients with macroalbuminuria, 2) Patients with congestive cardiac failure, urinary tract infection, 3) Ketonuria, 4) Pregnant patients, 5) Patients with overt diabetic nephropathy, The selected patients were studied in detail with history and physical examination. SUMMARY: We studied 100 Type II DM patients for detection of microalbuminuria through the dipstick method. The mean age between male and female and the mean age detection of DM is not statistically significant. 9 patients had severe microalbuminuria between 100 and 300 mg/dl. Incidence of microalbuminuria is 2.5 times more likely for the age group more than 50 years. All patients with HbA1C 7 with duration of DM > 15 years were positive for Microalbuminuria. Incidence of microalbuminuria is significantly associated with BMI > 25 kg/m^2. Incidence of microalbuminuria is 1.9 times more in patients with HDL < 30 mg /dl. CONCLUSIONS: The incidence of microalbuminuria is estimated to be 38% in this study. Microalbuminuria shows a direct relationship with increasing age of patients and increasing duration of diabetes mellitus since diagnosis. A HbA1c value above 7% is associated with 50% or higherincidence of microalbuminuria. Patients with a body mass index of more than 25kg/m2 have significant increasein the incidence of microalbuminuria. Incidence of microalbuminuria is significantly associated with presence of hypertension, neuropathy, Ischemic heart disease, retinopathy and high body mass index. Microalbuminuria is inversely associated with HDL.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Microalbuminuria, Risk Factors, complications, Type II Diabetes Mellitus. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Feb 2020 18:13 |
| Last Modified: | 27 Feb 2020 18:13 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/12041 |
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