Janet Sugantha, M (2011) Evaluation of Alterations in Autonomic Nervous System (HRV Analysis) and Central Nervous System (VEP) in Type 1 Diabetes Mellitus patients. Other thesis, Stanley Medical College, Chennai.
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Abstract
The aim of the study was to evaluate the cardiovascular autonomic function and central nervous system alterations in Type 1 diabetes mellitus patients. The study group consisted of 30 Type 1 diabetes mellitus patients attending Diabetology OPD, SMC. The control group consisted of 30 healthy subjects matched for age, sex and BMI. 2 tests were performed- HRV and VEP. 1. HRV analysis was done to evaluate Autonomic function. The following HRV indices were calculated- SDNN, RMSSD, NN50, pNN50 in the Time domain and LF, HF, LF/HF, LFnu and HFnu in the frequency domain. Overall HRV as measured by SDNN was significantly reduced. There was a significant reduction in HF. LF power was significantly higher in diabetics compared to controls. All these observations taken together signify vagal neuropathy. 2. VEP was also recorded in the same subjects. There was a significant prolongation of the latencies of P100, N75 and there was a significant reduction in amplitude of the VEP waveform in the diabetic group compared to controls. This shows that there is delayed conduction in the optic pathways in diabetics. This study has effectively shown that autonomic dysfunction can be detected very early, in the asymptomatic period, using heart rate variability analysis. It has also proved that VEP is a valuable method to detect early involvement of the optic pathway. Hence these tests can be considered as useful screening tests for type 1 diabetic patients.
| Item Type: | Thesis (Other) |
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| Uncontrolled Keywords: | Alterations, Autonomic Nervous System (HRV Analysis), Central Nervous System (VEP), Type 1 Diabetes Mellitus patients. |
| Subjects: | MEDICAL > Physiology |
| Depositing User: | Subramani R |
| Date Deposited: | 17 Jan 2020 01:18 |
| Last Modified: | 01 Feb 2021 08:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11871 |
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