Tumour necrosis factor alpha gene polymorphisms and hospital outcomes in acute pancreatitis

Jiffy Rasak, V A (2014) Tumour necrosis factor alpha gene polymorphisms and hospital outcomes in acute pancreatitis. Masters thesis, Christian Medical College, Vellore.

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Abstract

AIM OF THE STUDY: To study the clinical profile and in- hospital outcomes of patients presenting with acute pancreatitis and to determine whether there is any association between TNF alpha gene polymorphisms [TNF 308 G/A(rs1800629), TNF 857 C/T (rs1799724) ,TNF 863 C/A (rs1800630)] with severity of illness and hospital outcomes in patients with acute pancreatitis. MATERIAL AND METHODS: All patients with acute pancreatitis admitted to CMC between September 2012 and December 2013 were included in the study. Those with evidence of chronic pancreatitis were excluded. The in hospital course of these patients were followed up. The local complications, systemic complications and mortality in the study population was noted. Those patients with any local or systemic complication were classified as having severe disease. Atlanta 2012 criteria used to define complications. In all patients three TNF alpha gene polymorphisms were studied TNF 308G/A, TNF 857 C/T and TNF 863 C/A. Through this study we attempted to find out if there is any correlation between the severity of illness and these polymorphisms. RESULTS: A total of 168 patients were studied. 43% of patients had mild acute pancreatitis while 57% of patients had severe acute pancreatitis. The mortality in our study population was 8.9%. TNF 857C/T polymorphisms showed significant correlation with local complications, systemic complications and severity of illness in patients with acute pancreatitis. TNF 308G/A and TNF 863C/A polymorphisms did not show any significant correlation with the outcomes of acute pancreatitis. CONCLUSIONS: TNF 857 C/T polymorphisms showed significant correlation with the outcomes of acute pancreatitis. This molecular marker might serve as a valuable tool to prioritize patients for more aggressive management.

Item Type: Thesis (Masters)
Additional Information: Reg.No.: 16112753
Uncontrolled Keywords: Acute pancreatitis, severity, mortality, local complications, systemic complications, TNF alpha polymorphism.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 15 Jan 2020 15:55
Last Modified: 15 Jan 2020 15:55
URI: http://repository-tnmgrmu.ac.in/id/eprint/11847

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