Muthukumar, N J (2016) Therapeutic Efficacy of Vishnu Chakara Mathirai - A Siddha Formulation in the management of Valippu Noi (Convulsive Disorders): A Pre-Clinical study. Doctoral thesis, The Tamilnadu Dr. M.G.R. Medical University, Chennai.
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Abstract
The Vishnu Chakara Mathirai possess the specified charcters as mentioned by the Pharmacopoeial Laboratory for Indian Medicine, Ministry of AYUSH. • The phytochemical analysis revealed the presence of alkaloids and phenols which may helpful for the therapeutic efficacy. • The ICP OES analysis revealed that the toxic elements like mercury, arsenic, cadmium, lead and sulphur were found to be WHO permissible limits. • The spectral studies revealed the fingerprint of VCM which can be used for its bulk production. • The SEM and EXAX analysis showed the basic elements present in VCM as well as the external morphology of Vishnu Chakara Mathirai. • The TLC and HPTLC finger printing is much helpful in identifying the active principle in VCM. • The drug VCM was found to the safe as the LD50 level was fall above 2000mg/kg.b.wt. • The NOEAL level was found to be > 200 mg/kg b.wt. • The subacute and subchronic toxicity study revealed no toxic effects in the animals. • Efficacy studies revealed good antiepileptic activity as it controls the maximum electro shock in rats, Picrotoxin induced seizures in mice, Picrotoxin induced kindling as well as seizures and N-Methyl-D-Aspartate (NMDA) test in mice. CONCLUSION: The present study was undertaken to establish the literature that Vishu Chakara Mathirai (VCM), a herbo mineral formulation of Siddha system of medicine, would be effectively used against epilepsy (Valippu Noi), through various animal models. The safety as well as efficacy of VCM was studied extensively using standard and recommended scientific techniques. The trial drug VCM was found to be both safe and effective in epilepsy among animal models. The findings are strongly supportive of the traditional claim and use of VCM as an anti-epleptic medicine. From this study findings, it is also recommended that the medicine VCM can be taken for further research in the form of pharmacokinetic and pharmacodynamic studies as well clinical trials among human subjects to further establish the finding of this study. RECOMMENDATIONS: As VCM shows very good anti epileptic activity in animal models, therefore it is recommended for a pharmacokinetic and pharmacodynamic study. The drug is also be recommended for a clinical trial in epileptic patients.
| Item Type: | Thesis (Doctoral) |
|---|---|
| Uncontrolled Keywords: | Therapeutic Efficacy, Vishnu Chakara Mathirai, Siddha Formulation, Valippu Noi (Convulsive Disorders), Pre-Clinical study. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 14 Jan 2020 17:24 |
| Last Modified: | 15 Oct 2022 14:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11835 |
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