Maniyarasi, M (2012) Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac using different Polymers. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu, India.
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Abstract
Drug delivery system should aid in the optimization of drug therapy by delivering an appropriate amount to the intended site and at a desired rate. Hence, the DDS should deliver the drug at a rate dictated by the needs of the body over the period of treatment. An oral drug delivery system providing a uniform drug delivery can only partly satisfy therapeutic and biopharmaceutical needs, as it doesn‟t take in to account the site specific absorption rates within the gastrointestinal tract (GIT). Therefore there is a need of developing drug delivery system that release the drug at the right time, at the specific site and with the desired rate. In the present study the effect of types and concentration of polymer were studied on In-Vitro drug release. It shows that increase in concentration of polymer results in the sustained drug release for 8 hours. The study has revealed that by increasing concentration of polymer, release rate of drug was retarded and results confirmed that the release rate from hydrophilic matrix tablets depends on type and concentration of polymer. In present studies, matrix formulation containing Xanthan gum 40% is probably showing release up to 78% within 8 hrs according to stability study it was found that there was no significant change in hardness, drug content and in vitro dissolution of optimized formulation (F9).
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Evaluation; Sustained Release Matrix Tablets; Aceclofenac; Polymers |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 09:00 |
| Last Modified: | 06 Jul 2017 09:00 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1172 |
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