Palusuru, Sushma (2012) Formulation and In- Vitro Evaluation of Atorvastatin Calcium Immediate Release Pellets. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamil Nadu, India.
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Abstract
The term drug delivery covers a very broad range of techniques used to get therapeutic agents into the human body. The limitation of the most obvious and trusted drug delivery techniques, those of the ingested tablet and of the intravenous (IV)/ subcutaneous (SC)/ intramuscular (IM) injections, have been recognized for some time now. The former delivers drug into the blood only through the hepatic system, and hence the amount in the blood stream may be much lower than the amount formulated into the tablet (ie; it has low bioavailability); furthermore, liver damage is an unfortunate side effect of many soluble tabletted drugs. The injection mode of delivery can be used to deliver any size of drug molecule and is versatile in this regard, but it suffers from the obvious. stability study it was found that there was no significant change in hardness, drug content, percentage friability and in-vitro drug released of optimized formulation F4. It may be concluded that the Immediate released pellets of Atorvastatin calcium was feasible and may be manufactured with reproducible characteristics with the aid of crosspovidone (8%) as a superdisintegrant. However it needs further in depth animal studies on suitable animal models with statistical clinical data for a dependable and successful pharmaceutical marketing formulation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; In- Vitro Evaluation; Atorvastatin Calcium; Immediate Release Pellets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 07:45 |
| Last Modified: | 06 Jul 2017 07:45 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1162 |
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