Raga Keerthi, B (2012) Effect Of Super Disintegrating Agent And Lubricant On Optimized Fast Disintegrating Tablets Of Verapamil Hydrochloride. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode,Tamil Nadu, India.
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Abstract
Drug delivery systems are a magic tool for existing drug to enhance the safety and efficacy of the drug molecule by formulating a dosage form being for the administration. Due to impaired swallowing ability, (dysphasia) it is common among all age groups, especially in elderly, mainly it is seen in swallowing conventional tablets and capsules. In recent years, in accordance with changes in lifestyle, a demand has arisen for the development of dosage forms that can be readily handled and taken by many patients. The oral fast disintegrating tablets is also known as fast dissolve, rapid dissolve, rapid melt and quick disintegrating tablets, however the function and concept of all these dosage forms are similar. The application of full factorial design was useful in evaluating influence of disintegrating agent (crosscarmellose Sodium) concentration and lubricant (magnesium stearate) concentration on an optimized fast disintegrating formulation of Verapamil hydrochloride. From the statistical design, crosscarmallose Sodium concentration had an influence on the disintegration time and tablet hardness. 1.5% magnesium stearate concentration was selected as an optimum concentration where it has an influence on disintegration time and hardness of the optimized fast disintegrating tablet formulation. From the in-vitro drug release studies Ff7 was taken as the best formulation. Further it is recommended to perform in-vivo studies for the fast disintegrating tablets of Verapamil hydrochloride
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Super Disintegrating Agent; Lubrican; Optimized Fast Disintegrating Tablets; Verapamil Hydrochloride |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 07:37 |
| Last Modified: | 06 Jul 2017 07:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1160 |
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