A Study on Clinicomicrobiological Pattern in Chronicdiabetic Ulcer Foot Patients

Vinothkumar, Nallathambi (2019) A Study on Clinicomicrobiological Pattern in Chronicdiabetic Ulcer Foot Patients. Masters thesis, Coimbatore Medical College, Coimbatore.


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INTRODUCTION: Foot infections are one of the major complications of diabetes mellitus and are a significant risk factor for lower extremity amputation. Providing effective antimicrobial therapy is an important component in treating these infections. This study assesses themicrobial isolates of patients with diabetic foot infections and their antibioticsusceptibility pattern and to know the outcome in the antibiotic therapy which help in preventing amputations. AIMS AND OBJECTIVES: The main aim and objectives for this study is to analyse the types of Bacteria causing wound infections in Diabetic patients in our hospital and also todetermine the antimicrobial susceptibility pattern of the frequently isolated Bacteria. Also to perceive the extended spectrum Beta-lactamase creators among Gram Negative Bacteria. • To frame and device an emperical hospital antimicrobial strategy for patients with diabetic ulcers. • And to guide the treatingclinician with early bacteriological diagnosis and appropriate anti-microbial selection which can retrieve the organ from amputation which inturndecrease the morbidity and mortality. PATIENTS AND METHODS: A prospective study of 50 patients with diabetic foot infections admitted to Coimbatore medical college hospitals, Tamilnadu was undertaken. Bacteriological specimens were obtained and processed using standard hospital procedure for microbiological culture and sensitivity testing. RESULTS: A total of 52 pathogens were isolated. Thirty three percent of patients had polymicrobial infection, Sixty seven (52%) had single organism infections, and two (2%) had no growth. Gram-negative bacteria (67%) were more commonly isolatedcompared with Gram-positive bacteria (30%). The three most frequently found Grampositiveorganisms were Staphylococcus aureus (28%), and the most common Gram-negativeorganisms were Escherichia coli (32%), Proteus mirabilis (16%). Occurence of MDRO is 34 percent .Vancomycin was found to be the most effective againstGram-positive bacteria, whereas imipenem and amikacin were most effective againstGram-negative bacteria on antibiotic testing. CONCLUSION: Forty percent of diabetic foot infections were polymicrobial. S. aureus andEscherichia coli were the most common Gram-positive and Gram-negative organisms, respectively. Amputation rates in those treated patients were 28 percent. This study helps us to choose empirical antibiotics for patients withdiabetic foot infections.

Item Type: Thesis (Masters)
Uncontrolled Keywords: bacteriological, diabetic foot, Diabetic ulcer, Bacteriological Spectrum, amputation, multidrug resistant organism.
Subjects: MEDICAL > General Surgery
Depositing User: Subramani R
Date Deposited: 02 Sep 2019 07:16
Last Modified: 07 Sep 2019 04:04
URI: http://repository-tnmgrmu.ac.in/id/eprint/11405

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