Sowjanya, M (2012) Formulation and In-Vitro Evaluation of Mebeverine Hydrochloride Colon Targeted Micropellets for The Treatment of Irritable Bowel Syndrome. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur.
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Abstract
Colon is being extensively investigated as a drug delivery site. Colon targeted drug delivery system (CTDDS) has been developed by means of one or more controlled released mechanisms. It is convenient for treating localized colonic diseases, i.e. Ulcerative colitis, Crohn’s diseases and constipation etc. During the in-vitro drug release study, on exposure to the dissolution fluid, the micropellets slows down further seeping-in of dissolution fluids towards the interior of the pellets. Once the gel layer is formed the drug release takes place mainly by diffusion from the inner region. On reaching the colonic environment the polymeric layer would soluble at colonic pH and release the major amount of drug in the region of colon. In the in-vitro drug release study, the drug release from the micropellets required a longer time in experimental conditions. But in actual use in living systems these limitations for pH environment and it will never be felt. Therefore the micropellets will be take place completely and rapidly in the colon region. While analyzing the drug release pattern of the drug from the micropellets, it was found that the drug release started in the early hours of study. This was due to change in pH.Out of the nine formulations, it appears that F7 has the maximum potential in providing colon targeted drug delivery.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation ; In-Vitro ; Evaluation ; Mebeverine Hydrochloride ; Colon Targeted Micropellets ; Treatment ; Irritable Bowel Syndrome. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 06:45 |
| Last Modified: | 22 Dec 2018 05:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1137 |
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