Serum Titanium Estimation in Postoperative Individuals with Titanium Implant using Inductively Coupled Plasma Mass Spectrometry and Its Clinical Correlation

Shreyas, Doddihithlu (2019) Serum Titanium Estimation in Postoperative Individuals with Titanium Implant using Inductively Coupled Plasma Mass Spectrometry and Its Clinical Correlation. Masters thesis, Coimbatore Medical College, Coimbatore.

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Abstract

INTRODUCTION: Increased concentration of circulating metal degradation products derived from the use of Titanium based orthopaedic implants may have deleterious effects over the long term. Therefore there is a need to analyse the levels of titanium in the body of the population with titanium implants to know any toxicity using appropriate highly sensitive techniques and strategies. AIM OF THE STUDY: To estimate levels of titanium in serum of patients with titanium implants and toxicity signs if any. METHODS: Blood samples of 25 patients of age group 5-75 years with titanium implants is collected over a predetermined duration of time, centrifuged and then it is subjected to triple acid digestion and then analysed through Inductive coupled plasma mass spectroscopy (ICP-MS) and the blood levels identified. RESULTS: The serum titanium levels were within the normal range that is less than 7.2 microgram per litre. There was no signs and symptoms of toxicity which could be directly related to serum titanium levels. Similar to the previously conducted studies in literature there was no significant difference between the sides or sex of the patients. The detection level in our study was still more precise as it was done using inductively coupled plasma mass spectrometry whereas in many of the early studies atomic absorption spectrometry was used. CONCLUSION: Serum titanium levels were within the normal level and did not show any signs of toxicity. Bilateral hip replacement patients had higher level of serum titanium level compared to unilateral hip replacement patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Titanium, ICPMS, total hip replacement, triple acid digestion.
Subjects: MEDICAL > Orthopaedics
Depositing User: Subramani R
Date Deposited: 01 Sep 2019 09:53
Last Modified: 01 Sep 2019 09:53
URI: http://repository-tnmgrmu.ac.in/id/eprint/11362

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