Sreenivaasa Reddy, Y (2012) Formulation and Evaluation of Bilayered Tablets of Acetaminophen and Methocarbamol. Masters thesis, R V S College of Pharmaceutical Sciences, Coimbatore, Tamilnadu, India.
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Abstract
The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action tablet. The present study was aimed at developing a bilayer tablet of Acetaminophen and Methocarbamol. Acetaminophen is used as an Analgesic, Non-Narcotic, antipyretic, Methocarbamol is used as an Anti-inflammatory, skeletal muscle relaxant. Totally 9 formulations are prepared with Acetaminophen and Methocarbamol granules prepared separately in a rapid mixer granulator. Pre compression parameters like Bulk density, True density, Angle of repose indicate all the formulations are showing good flow properties. Tablets are compressed using SEJONG bilayer compression machine and tablets are evaluated for post compression parameters Weight variation, Hardness, Friability, Disintegration and Dissolution parameters. Among all the formulations F8 is showing the release profile similar to the Innovator. The compressed bilayer tablets was packed in blisters and subjected to stability studies at 40⁰C and 75% RH, 25⁰C and 60% RH. Samples were analyzed at regular intervals as mentioned in stability protocol. From the study, it may be concluded that bilayer tablet of Acetaminophen and Methocarbamol can be prepared as immediate release formulation compared to conventional formulations.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Evaluation; Bilayered Tablets; Acetaminophen; Methocarbamol |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 06:37 |
| Last Modified: | 06 Jul 2017 06:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1134 |
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