Enhanced Dissolution and In-Vivo Biavailability of Itraconazole Cyclodextrin Complex.

Srihari, Kalyanam (2012) Enhanced Dissolution and In-Vivo Biavailability of Itraconazole Cyclodextrin Complex. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode,Tamil Nadu, India.

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Abstract

Oral route is the most preferred for administration of drugs owing to its known advantage of better patient compliance. Drugs administered by oral route should dissolve in gastric and intestinal fluid before they permeate through the membrane of GI tract and enter into systemic circulation. So solubility is a prerequisite for absorption of drugs. Co-precipitation of 1:4 (drug: CD) showed higher dissolution as compared to co-precipitation 1:2 (drug: CD) physical mixture (1:2,1:4) ( drug: CD) andpure Itraconazole. Dissolution amounts of co-precipitate increased as the pH of acidic environment increased. Solubility of Itraconazole was improved with higher concentrations of CD. Inclusion complex formation was detected in co-precipite’s as observed in the DSC thermograms. Physical mixture did not show interaction between Itraconazole and CD as supported by the results of FTIR spectra and DSC analysis. The enhanced dissolution of Itraconazole from co-precipitate of 1:4 (drug: CD) was reflected in improved pharmacokinetics of co-precipitate. The results of the study proposes that the dissolution and bio-availability of Itraconazole can be improved by using cyclodextrin, how ever bioavailability of Itraconazole can be influenced by the pH conditions of the gastric environment as evident from dissolution study. Further studies are warranted to examine the effect of food on the bio availability of Itraconazole cyclodextrin complex.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Enhanced; Dissolution; In Vivo; Biavailability; Itraconazole; Cyclodextrin Complex
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 06 Jul 2017 06:30
Last Modified: 06 Jul 2017 06:30
URI: http://repository-tnmgrmu.ac.in/id/eprint/1133

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