Shivanathan, M (2019) Correlation of Serum Amylase, Lipase and Creatine Kinase in Predicting the severity of Organophosphorus Poisoning. Masters thesis, Madras Medical College, Chennai.
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Abstract
BACKGROUND: Organophosphorus Compounds (OPC) are widely used poison especially in India due to easy availability and low cost. Serum Acetylcholine esterase (AchE) measured in acute OPC poisoning is not specific and does not correlate with severity of poisoning. This study is undertaken to know the efficacy of Serum levels of Amylase, Lipase and Creatine Kinase (CK) in predicting the severity of OPC poisoning. OBJECTIVES: To estimate the Serum levels of Amylase, Lipase and CK in acute OPC poisoning on admission and serially till discharge or death and to correlate the same with POP scale, complications, Intermediate Syndrome (IMS), mechanical ventilation requirement and outcome. METHODS: An observational study done consisting of 100 patients at Toxicology ward, Institute of Internal Medicine RGGGH, Chennai for a period of 6 months. Patient selected after applying inclusion and exclusion criteria and statistical analysis was done. RESULTS: In our study, raised serum Amylase, Lipase and CK levels significantly correlated with initial clinical severity by POP Scale, IMS, complications, ventilation requirement and outcome. It also had a negative correlation with Serum AchE levels. CONCLUSION: We conclude that increased Serum levels of Amylase, Lipase and CK correlated with poor clinical outcome and can be used as newer biochemical markers in predicting the severity of OPC poisoning.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Organophosphorus Compound, Acetyl choline esterase, Amylase, Lipase, Creatine Kinase, POP Scale, Intermediate Syndrome. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Aug 2019 05:28 |
| Last Modified: | 31 Aug 2019 17:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11265 |
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